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An amino-acid taste receptor
This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
The receptors and cells for mammalian taste
The emerging picture of taste coding at the periphery is one of elegant simplicity, it is now clear that distinct cell types expressing unique receptors are tuned to detect each of the five basic tastes.
The cells and logic for mammalian sour taste detection
It is proposed that PKD2L1 cells correspond to the long-sought components of the cerebrospinal fluid chemosensory system, and a common basis for acid sensing in disparate physiological settings is suggested.
The cells and peripheral representation of sodium taste in mice
These studies substantiate independent cellular substrates for all five basic taste qualities, and validate the essential role of ENaC for sodium taste in mice.
Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area
Together, these results implicate the extracellular generation of protons, rather than intracellular acidification, as the primary signal that mediates the taste of CO2, and demonstrate that sour cells not only provide the membrane anchor for Car4 but also serve as the cellular sensors for carbonation.