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- Publications
- Influence
Mammalian Sweet Taste Receptors
- Greg Nelson, M. Hoon, J. Chandrashekar, Y. Zhang, N. Ryba, C. Zuker
- Biology, Medicine
- Cell
- 10 August 2001
The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitter… Expand
An amino-acid taste receptor
- Greg Nelson, J. Chandrashekar, +4 authors C. Zuker
- Biology, Medicine
- Nature
- 14 March 2002
The sense of taste provides animals with valuable information about the nature and quality of food. Mammals can recognize and respond to a diverse repertoire of chemical entities, including sugars,… Expand
The Receptors for Mammalian Sweet and Umami Taste
Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromeric… Expand
Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways
Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds. Here, we demonstrate… Expand
T2Rs Function as Bitter Taste Receptors
- J. Chandrashekar, K. Mueller, +5 authors N. Ryba
- Biology, Medicine
- Cell
- 17 March 2000
Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putative… Expand
The receptors and cells for mammalian taste
- J. Chandrashekar, M. Hoon, N. Ryba, C. Zuker
- Biology, Medicine
- Nature
- 16 November 2006
The emerging picture of taste coding at the periphery is one of elegant simplicity. Contrary to what was generally believed, it is now clear that distinct cell types expressing unique receptors are… Expand
A Novel Family of Mammalian Taste Receptors
- E. Adler, M. Hoon, K. Mueller, J. Chandrashekar, N. Ryba, C. Zuker
- Biology, Medicine
- Cell
- 17 March 2000
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells of… Expand
The cells and logic for mammalian sour taste detection
- Angela L. Huang, Xiaoke Chen, +5 authors C. Zuker
- Biology, Medicine
- Nature
- 24 August 2006
Mammals taste many compounds yet use a sensory palette consisting of only five basic taste modalities: sweet, bitter, sour, salty and umami (the taste of monosodium glutamate). Although this… Expand
The cells and peripheral representation of sodium taste in mice
- J. Chandrashekar, C. Kuhn, +4 authors C. Zuker
- Chemistry, Medicine
- Nature
- 27 January 2010
Salt taste in mammals can trigger two divergent behavioural responses. In general, concentrated saline solutions elicit robust behavioural aversion, whereas low concentrations of NaCl are typically… Expand
The receptors and coding logic for bitter taste
- Ken L. Mueller, M. Hoon, I. Erlenbach, J. Chandrashekar, C. Zuker, N. Ryba
- Biology
- Nature
- 10 March 2005
The sense of taste provides animals with valuable information about the nature and quality of food. Bitter taste detection functions as an important sensory input to warn against the ingestion of… Expand
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