J. Chandrashekar

Publications48
h-index23
Citations11,604
Highly Influential Citations739
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Mammalian Sweet Taste Receptors
An amino-acid taste receptor
TLDR
This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
The Receptors for Mammalian Sweet and Umami Taste
T2Rs Function as Bitter Taste Receptors
Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways
The receptors and cells for mammalian taste
TLDR
The emerging picture of taste coding at the periphery is one of elegant simplicity, it is now clear that distinct cell types expressing unique receptors are tuned to detect each of the five basic tastes.
A Novel Family of Mammalian Taste Receptors
The cells and logic for mammalian sour taste detection
TLDR
It is proposed that PKD2L1 cells correspond to the long-sought components of the cerebrospinal fluid chemosensory system, and a common basis for acid sensing in disparate physiological settings is suggested.
The cells and peripheral representation of sodium taste in mice
TLDR
These studies substantiate independent cellular substrates for all five basic taste qualities, and validate the essential role of ENaC for sodium taste in mice.
Sequential Processing of Lexical, Grammatical, and Phonological Information Within Broca's Area
TLDR
Together, these results implicate the extracellular generation of protons, rather than intracellular acidification, as the primary signal that mediates the taste of CO2, and demonstrate that sour cells not only provide the membrane anchor for Car4 but also serve as the cellular sensors for carbonation.
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