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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
The data implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries as well as in two independent Japanese populations, and the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of β-cell function or the corrected insulin response.
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene…
Practical recommendations for the management of diabetes in patients with COVID-19
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
Results from eight case-control groups demonstrate that this variant in TCF2 (HNF1β), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5, confers protection against type 2 diabetes.
Variants conferring risk of atrial fibrillation on chromosome 4q25
A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk—a review of the literature
- R. Huxley, S. Mendis, E. Zheleznyakov, S. Reddy, J. Chan
- Medicine, BiologyEuropean Journal of Clinical Nutrition
Overweight and obesity have become a major public health problem in both developing and developed countries as they are causally related to a wide spectrum of chronic diseases including type II…
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
A significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association is observed, and considerable improvements in the fine-mapping resolution of common variant association signals at several T1D susceptibility loci are observed.
IDF diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF is identified, and this variant also associated with ischemic stroke and cardioembolic stroke in a combined analysis of five stroke samples.