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Potency of 5-hydroxytryptamine1a agonists to inhibit adenylyl cyclase activity is a function of affinity for the "low-affinity" state of [3H]8-hydroxy-N,N-dipropylaminotetralin ([3H]8-OH-DPAT)
In this study, the radiolabeled 5-hydroxytryptamine1A agonist, [3H]8-hydroxy-N,N-dipropylamino tetralin ([3H]8-OH-DPAT), was shown to have both a high (Kd, 0.7 +/- 0.2 nM) and a low (Kd, 17 +/- 4 nM)Expand
The Analysis of Drugs in Biological Fluids
Why Analyze Drugs in Biological Fluids? Special Problems with Biological Fluids. Special Problems in Structures of Drugs. Spectroscopy and Fluorimetry. Planar Chromatography. Gas Chromatography.Expand
Journal of Pharmacy and Pharmacology and the Electronic Publishing Revolution
  • J. Chamberlain
  • Medicine
  • The Journal of pharmacy and pharmacology
  • 1 July 1999
Conference Report: Analytical challenges in the qualification and validation of pharmacodynamic biomarkers.
TLDR
This 1-day workshop discussed current concepts in the qualification and validation of biomarker assays for the measurement of pharmacodynamic responses to drugs and vaccines. Expand
Science Symposia at the British Pharmaceutical Conference
  • J. Chamberlain
  • Medicine
  • The Journal of pharmacy and pharmacology
  • 1 April 1998
Editorial—What is the point of pharmacokinetics?
Any major disaster-such as a train or plane crash, sinking of a ferry, or collapse of a bank-seems to be inevitably followed by the clamour of politicians calling for a public enquiry. More personalExpand
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