• Publications
  • Influence
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Brain Rewiring After Stress Chronic stress, mainly through the release of corticosteroids, affects executive behavior through sequential structural modulation of brain networks. Stress-inducedExpand
  • 622
  • 32
The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
The mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis andExpand
  • 467
  • 30
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress
Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress-related disorders, we hereExpand
  • 476
  • 27
Dissociation of the morphological correlates of stress‐induced anxiety and fear
Chronic stress is a powerful modulator of emotional behaviour. Previous studies have shown that distinct neuronal pathways modulate different emotional behaviours: while the amygdala plays a key roleExpand
  • 137
  • 21
Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors
Imbalances in the corticosteroid milieu have been implicated in several neuropsychiatric disorders, including depression and schizophrenia. Prefrontal cortex (PFC) dysfunction is also a hallmark ofExpand
  • 269
  • 18
A Trans-Dimensional Approach to the Behavioral Aspects of Depression
Depression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook aExpand
  • 383
  • 8
Specific configuration of dendritic degeneration in pyramidal neurons of the medial prefrontal cortex induced by differing corticosteroid regimens.
We previously demonstrated that hypercorticalism induces pronounced volumetric reductions in the rat medial prefrontal cortex (mPFC) and that these structural changes correlate with deficits inExpand
  • 148
  • 7
Stress-induced changes in human decision-making are reversible
Appropriate decision-making relies on the ability to shift between different behavioral strategies according to the context in which decisions are made. A cohort of subjects exposed to prolongedExpand
  • 104
  • 6
Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats
Interest in astroglial cells is rising due to recent findings supporting dynamic neuron–astrocyte interactions. There is increasing evidence of astrocytic dysfunction in several brain disorders suchExpand
  • 57
  • 5
Differential impact of chronic stress along the hippocampal dorsal–ventral axis
Abstract Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functionalExpand
  • 47
  • 5