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From mice to men: lessons from mutant ataxic mice
Ataxic mutant mice can be used to represent models of cerebellar degenerative disorders. They serve for investigation of cerebellar function, pathogenesis of degenerative processes as well as ofExpand
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Ataxic gait analysis in a mouse model of the olivocerebellar degeneration
Lurcher mutant mice represent a model of olivocerebellar degeneration. Postnatally, a complete loss of Purkinje cells and secondary reduction of granule cells and inferior olive neurons occurs.Expand
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Purkinje cell loss affects differentially the execution, acquisition and prepulse inhibition of skeletal and facial motor responses in Lurcher mice
Adult heterozygous Lurcher mice show a degeneration of almost all Purkinje cells and 90% of the granular cells of the cerebellum, resulting in ataxia or general deficits in motor coordination. TheseExpand
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Behavioral characteristics, associative learning capabilities, and dynamic association mapping in an animal model of cerebellar degeneration.
Young adult heterozygous Lurcher mice constitute an excellent model for studying the role of the cerebellar cortex in motor performance-including the acquisition of new motor abilities-because of theExpand
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Microcirculation of the brain: morphological assessment in degenerative diseases and restoration processes
Abstract Brain microcirculation plays an important role in the pathogenesis of various brain diseases. Several specific features of the circulation in the brain and its functions deserve specialExpand
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IEC1131-3 Programming methodology
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The effect of repeated rotarod training on motor skills and spatial learning ability in Lurcher mutant mice
Lurcher mutant mice represent a model of olivocerebellar degeneration. Due to loss of Purkinje cells, they suffer from functional cerebellar decortication resulting in ataxia and deterioration ofExpand
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Role of leukemia inhibitory factor in the nervous system and its pathology
Abstract Leukemia inhibitory factor (LIF) is a multifunction cytokine that has various effects on different tissues and cell types in rodents and humans; however, its insufficiency has a relativelyExpand
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Near‐complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase
J. Neurochem. (2012) 122, 1065–1080.
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A Preliminary Study of Solid Embryonic Cerebellar Graft Survival in Adult B6CBA Lurcher Mutant and Wild Type Mice
Lurcher mutant mice represent a model of olivocerebellar degeneration. They suffer from complete loss of Purkinje cells and a reduction of granule cells and inferior olive neurons. Their wild typeExpand
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