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Synthesis and antimalarial activity of new haemanthamine-type derivatives.
Thirty one derivatives of haemanthamine were prepared from the natural alkaloids and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and some structure-activity relationships were outlined. Expand
Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines was determined and some structure-activity relationships were outlined. Expand
Synthesis and antiplasmodial activity of lycorine derivatives.
Twenty seven lycorine derivatives were prepared and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and the higher values were obtained with the replacement of the methylenedioxy moiety by hydroxyl or acetate groups and with methyl substituent attached to the nitrogen atom. Expand
Pancratium canariense as an important source of amaryllidaceae alkaloids.
Four new alkaloids have been isolated from a methanolic extract of bulbs of Pancratium canariense and the structures were determined by extensive 1D and 2D NMR spectroscopic studies and X-ray diffraction. Expand
Synthesis of New Hydrogels by Copolymerization of Poly(2‐methyl‐2‐oxazoline) Bis(macromonomers) and N‐Vinylpyrrolidone
New non-ionic hydrogels were synthesized by radical homopolymerization of vinyl end-functionalized poly(2-methyl-2-oxazoline) bis(macromonomers), or by radical copolymerization of theseExpand
Preparation and antimalarial activity of semisynthetic lycorenine derivatives.
The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers, being the hippEastrine dimers the most active compounds. Expand
Análisis de biodiesel preparado a partir de residuos de aceite doméstico, mediante RMN
1 espectro de H-RMN permitio calcular que la conversion de trigliceridos en esteres monoalquilados fue del 98,82%, lo cual indica que el biodiesel tiene la calidad recomendada. Se propone el metodoExpand
Bioactive montanine derivatives from halide-induced rearrangements of haemanthamine-type alkaloids. Absolute configuration by VCD.
An unexpected rearrangement of haemanthamine-type alkaloids in the presence of halogenating agents has been found and several rearranged alkaloid showed antimalarial activity. Expand
Chemistry and biology of Pancratium alkaloids.
This review covers the occurrence of alkaloids present in the Pancratium genus, the most relevant NMR characteristics for each of the alkaloid-types, the chemical synthesis, and the biological activities described for Pancratiods during the period 2005 until May 2009. Expand
Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses
Solidagenone derivative 5 and 6 showed significant anti-inflammatory effects, as they inhibited the protein expression of nitric oxide synthase, cyclooxygenase-2, and cytokine production induced by the ligand of TLR4, lipopolysaccharide (LPS), acting at the transcriptional level. Expand