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Successful Cardiopulmonary Resuscitation After Cardiac Arrest as a “Sepsis-Like” Syndrome
The high levels of circulating cytokines, the presence of endotoxin in plasma, and the dysregulated production of cytokines found in these patients recall the immunological profile found in patients with sepsis. Expand
Bench-to-bedside review: Endotoxin tolerance as a model of leukocyte reprogramming in sepsis
The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients. Expand
Cytokines and macrophages.
- J. Cavaillon
- Chemistry, Medicine
- Biomedicine & pharmacotherapy = Biomedecine…
Macrophages, within the cytokine network, are a major source of many cytokines involved in immune response, hematopoiesis, inflammation and many other homeostatic processes. Upon stimulation by… Expand
Dysregulation of in vitro cytokine production by monocytes during sepsis.
- C. Muñoz, J. Carlet, C. Fitting, B. Misset, J. Blériot, J. Cavaillon
- The Journal of clinical investigation
- 1 November 1991
The data indicate an in vivo activation of circulating monocytes during sepsis as well as in noninfectious shock and suggest that complex regulatory mechanisms can downregulate the production of cytokines by monocyte during severe infections. Expand
Some patients with septic shock might benefit from drugs such as corticosteroids or activated protein C, and other therapeutic strategies are under investigation, including those that target late proinflammatory mediators, endothelium, or the neuroendocrine system. Expand
Compensatory anti-inflammatory response syndrome.
Compensatory anti-inflammatory response syndrome may be considered as an adapted compartmentalized response with the aim to silence some acute proinflammatory genes, and to maintain the possible expression of certain genes involved in the anti-infectious process. Expand
Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
Although in all models the muscle regenerates completely, the trajectories of the regenerative process vary considerably, and it is shown that histological parameters are not wholly sufficient to declare that regeneration is complete as molecular alterations could have a major persistent impact. Expand
Structural and functional analyses of bacterial lipopolysaccharides.
- M. Caroff, D. Karibian, J. Cavaillon, N. Haeffner‐Cavaillon
- Biology, Medicine
- Microbes and infection
- 1 July 2002
Bacterial lipopolysaccharides are powerful immunomodulators in infected hosts, and may cause endotoxic shock because cells of the innate immune response recognize evolutionarily conserved LPS molecular patterns of endotoxins and structural details thereby greatly influencing their response. Expand
Gamma Interferon and Granulocyte/Monocyte Colony-stimulating Factor Prevent Endotoxin Tolerance in Human Monocytes by Promoting Interleukin-1 Receptor-associated Kinase Expression and Its Association…
These cytokines prevent endotoxin tolerance induced by low but not by high doses of LPS by inhibiting IRAK degradation and by promoting its association with MyD88 after a second LPS stimulation, which in turn leads to NF-κB activation and TNF production. Expand
Synergistic stimulation of human monocytes and dendritic cells by Toll‐like receptor 4 and NOD1‐ and NOD2‐activating agonists
- J. Fritz, S. Girardin, +6 authors M. Adib-Conquy
- Biology, Medicine
- European journal of immunology
- 1 August 2005
It is revealed here that NOD1 as well as NOD2 agonists act cooperatively with LPS to stimulate the release of both pro‐ and anti‐inflammatory cytokines in these myeloid cell subsets. Expand