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Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene.
- L. Benit, N. de Parseval, J. Casella, I. Callebaut, A. Cordonnier, T. Heidmann
- Biology, Medicine
- Journal of virology
- 1 July 1997
We had previously identified a new family of human endogenous retrovirus-like elements, the HERV-L elements (human endogenous retrovirus with leucine tRNA primer), whose pol gene was most closely… Expand
Members of the SRY family regulate the human LINE retrotransposons.
LINEs are endogenous mobile genetic elements which have dispersed and accumulated in the genomes of most higher eukaryotes via germline transposition, with up to 100 000 copies for the human LINE-1… Expand
Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change
Cytochalasins, a class of fungal metabolites, affect a wide variety of motile functions of eukaryotic cells1–3. Recently, several laboratories have shown that cytochalasins inhibit actin… Expand
Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.
- M. DeBaun, M. Gordon, +35 authors J. Casella
- The New England journal of medicine
- 20 August 2014
BACKGROUND Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct).… Expand
ERV-L Elements: a Family of Endogenous Retrovirus-Like Elements Active throughout the Evolution of Mammals
- L. Benit, J. Lallemand, J. Casella, H. Philippe, T. Heidmann
- Medicine, Biology
- Journal of Virology
- 1 April 1999
ABSTRACT We have previously identified in the human genome a family of 200 endogenous retrovirus-like elements, the HERV-L elements, disclosing similarities with the foamy retroviruses and which… Expand
Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls
BACKGROUND Up to 25% of adolescent girls in the USA are iron deficient. This double-blind, placebo-controlled clinical trial assessed the effects of iron supplementation on cognitive function in… Expand
Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence.
A new class of reverse transcriptase coding sequences was detected in reverse-transcribed RNAs from human placenta by polymerase chain amplification with primers in highly conserved regions of the… Expand
Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease.
Sickle cell disease is a common hemolytic disorder with a broad range of complications, including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme oxygenase-1 (gene HMOX1;… Expand
Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke.
OBJECTIVE To test the hypothesis that children with sickle cell disease (SCD) who have an initial stroke temporally unrelated to another medical event are at higher risk for recurrent stroke than are… Expand
Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial.
CONTEXT Inhaled nitric oxide has shown evidence of efficacy in mouse models of sickle cell disease (SCD), case series of patients with acute chest syndrome, and 2 small placebo-controlled trials for… Expand