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Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.
Mice deficient in beta(2)-microglobulin and interleukin 2 (beta(2)m(null) x IL-2(null)) spontaneously develop colon cancer in the setting of chronic ulcerative colitis (UC). We investigated mutations… Expand
Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species.
- M. Darsigny, Jean-Philippe Babeu, +5 authors François Boudreau
- Medicine, Biology
- Cancer research
- 15 November 2010
Hepatocyte nuclear factor-4α (Hnf4α) is a transcription factor that controls epithelial cell polarity and morphogenesis. Hnf4α conditional deletion during postnatal development has minor effects on… Expand
Cell-cell interactions between platelets, macrophages, eosinophils and natural killer cells in thromboxane A2 biosynthesis.
- K. Maghni, J. Carrier, S. Cloutier, P. Sirois
- Biology, Medicine
- Journal of lipid mediators
- 1 March 1993
Biosynthesis of thromboxane A2 (TxA2) during cell-cell interactions between platelets and alveolar macrophages, eosinophils and natural killer cells from guinea pigs has been investigated. The… Expand
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
A major risk factor of developing colorectal cancer (CRC) is the presence of chronic inflammation in the colon. In order to understand how inflammation contributes to CRC development, the present… Expand
Effects of dietary folate on colorectal carcinogenesis in a genetically-predisposed murine model of ulcerative colitis-associated colon cancer
Abstract 1305: Alternative splicing of the metabolic regulator Estrogen-Related Receptor alpha (ERRα) in colon carcinogenesis
680 Hnf4α Protects Against Reactive Oxygen Species and Promotes Gut Neoplasia
DISTRIBUTION OF ENDOTHELIAL MARKERS ALONG THE VASCULAR TREE
682 The Integrin a6a Splice Variant Regulates the Wnt/β-Catenin Pathway in Colon Cancer Cells
unstable as evidenced by the presence of high level of DNA damage, centrosome amplification, and aneuploidy. AIM: To investigate role and possible mechanisms of Klf4 in preserving genetic stability.… Expand
Short Communication Effects of Dietary Folate on Ulcerative Colitis-Associated Colorectal Carcinogenesis in the Interleukin 2- and 2 -Microglobulin- deficient Mice
Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and 2-microglobulin (2m)-deficient (IL-2 null… Expand