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Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain.
To compare the proportions of four muscarinic receptors in different rat brain regions, we used competition curves with four selective antagonists, at 1-[N-methyl-3H]scopolamine methyl chloride [(Expand
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Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP
Adenylate cyclase stimulation by GH-releasing factor (GRF) and 14 GRF analogs (modified in the N-terminal part) was compared to the capacity of the same peptides to inhibit [125I]iodo-vasoactiveExpand
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Rat pancreatic hydrolases from birth to weaning and dietary adaptation after weaning.
KoRBERECHT, P., M. DESCHODT-LANCKMAN, J. CAMUS, J. BRUYLANDS, AND J. CHRISTOPHE. Rat pancreatic hydrolases from birth to weaning and dietary adaptation cfter weaning. Am. J. Physi~l. 221(l): 376-381.Expand
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Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on
The efficacy and potency of 14 GH-releasing factor (GRF) analogs, substituted in position 1 to 7, on adenylate cyclase activation in crude homogenates from rat anterior pituitary were related toExpand
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Binding kinetics of quinuclidinyl benzilate and methyl-quinuclidinyl benzilate enantiomers at neuronal (M1), cardiac (M2), and pancreatic (M3) muscarinic receptors.
We analyzed the competition kinetics of quinuclidinyl benzilate (QNB) and QNB methiodide enantiomers on human NB-OK1 neuroblastoma (M1), rat cardiac (M2), and rat pancreas (M3) muscarinic bindingExpand
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Specific labelling by [125I]helodermin of high‐affinity VIP receptors in rat liver membranes
Helodermin, a newly isolated peptide from Gila Monster venom, is structurally related to VIP and secretin. When used as radioligand, [125I]helodermin bound rapidly and reversibly to crude rat liverExpand
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Short-term adaptation of pancreatic hydrolases to nutritional and physiological stimuli in adult rats.
Abstract o 1. Adult rats, previously maintained on a chow containing 48 p. cent carbohydrates, were fasted 24 h, then refed for 5 days on various diets. The nutritional stimuli were made up either ofExpand
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Secretin Receptors in Human Pancreatic Membranes
Crude membranes (27,000 g pellets) from five normal human pancreases were prepared. In the presence of GTP, the peptides of the secretin family stimulated adenylate cyclase activity, their order ofExpand
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80% of muscarinic receptors expressed by the NB‐OK 1 human neuroblastoma cell line show high affinity for pirenzepine and are comparable to rat hippocampus M1 receptors
The NB‐OK 1 human neuroblastoma cell line expressed muscarinic cholinergic receptors that could be labeled with N‐[3H]methylscopolamine (a nonselective antagonist). 80% of these receptors showed highExpand
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Pharmacology of hexahydro-difenidol, hexahydro-sila-difenidol and related selective muscarinic antagonists.
A series of hexahydro-difenidol (HHD) and hexahydro-sila-difenidol (HHSiD) analogues modified in the amino group, the phenyl ring and in the alkylene chain were investigated for their binding andExpand
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