J. Camus

Publications114
h-index27
Citations2,251
Highly Influential Citations32
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Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain.
TLDR
Himbacine and methoctramine were shown to discriminate two muscarinic receptor subtypes having a high affinity for 4-diphenylacetoxy-N-methylpiperidine methiodide and hexahydrosiladifenidol, intermediate affinity for pirenzepine, and low affinity for AF-DX 116.
Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP…
TLDR
Adenylate cyclase stimulation by GH-releasing factor (GRF) and 14 GRF analogs (modified in the N-terminal part) was compared to the capacity of the same peptides to inhibit [125I]iodo-vasoactive intestinal peptide (VIP) binding in rat pancreatic plasma membranes, and alterations in positions 6 and 7 markedly reduced the affinity of the resultingGRF analog.
Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth hormone-releasing factor (GRF): discovery of (N-Ac-Tyr1, D-Arg2)-GRF(1-29)-NH2 as a GRF antagonist on…
TLDR
It was possible to demonstrate that GRF and vasoactive intestinal peptide receptors represent distinct entities in the rat anterior pituitary.
Rat pancreatic hydrolases from birth to weaning and dietary adaptation after weaning.
TLDR
Comparison of enzyme activities in pancreas and in small and large intestines indicates that rates of biosynthesis and secretion were not the sole factors determining intestinal activities in weanling rats.
Secretin Receptors in Human Pancreatic Membranes
TLDR
It is tempting to conclude that the human pancreas possesses highly specific secretin receptors and such receptors could not fully account for the whole pattern of adenylate cyclase activation by related peptides, so that the presence of an added type of “helodermin- PHI-preferring” receptors is suggested.
Comparative structural requirements of thirty GRF analogs for interaction with GRF- and VIP receptors and coupling to adenylate cyclase in rat adenopituitary, liver and pancreas
Binding kinetics of quinuclidinyl benzilate and methyl-quinuclidinyl benzilate enantiomers at neuronal (M1), cardiac (M2), and pancreatic (M3) muscarinic receptors.
TLDR
The competition kinetics of quinuclidinyl benzilate and QNB methiodide enantiomers on human NB-OK1 neuroblastoma, rat cardiac, and rat pancreas muscarinic binding sites found that receptor stereoselectivity, when present, was associated with differences in unlabeled drug dissociation rate constants.
Specific labelling by [125I]helodermin of high‐affinity VIP receptors in rat liver membranes
Short-term adaptation of pancreatic hydrolases to nutritional and physiological stimuli in adult rats.
80% of muscarinic receptors expressed by the NB‐OK 1 human neuroblastoma cell line show high affinity for pirenzepine and are comparable to rat hippocampus M1 receptors
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