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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays toExpand
  • 2,048
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The senescence-associated secretory phenotype: the dark side of tumor suppression.
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can haveExpand
  • 1,784
  • 197
Cellular senescence: when bad things happen to good cells
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additionalExpand
  • 2,915
  • 108
Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments. The pathwaysExpand
  • 1,296
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Four faces of cellular senescence
Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells. Recently, however, it has become apparent that this process entails more than a simpleExpand
  • 1,337
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Aging, cellular senescence, and cancer.
  • J. Campisi
  • Medicine, Biology
  • Annual review of physiology
  • 11 February 2013
For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging alsoExpand
  • 1,270
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Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, andExpand
  • 1,889
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Inflammatory networks during cellular senescence: causes and consequences.
Chronic inflammation is associated with aging and plays a causative role in several age-related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this chronic inflammation isExpand
  • 768
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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is aExpand
  • 808
  • 58
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Most mammalian cells do not divide indefinitely, owing to a process termed replicative senescence. In human cells, replicative senescence is caused by telomere shortening, but murine cells senesceExpand
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