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Autoimmune rheumatic diseases in the intensive care unit: experience from a tertiary referral hospital and review of the literature
The results reveal a lower mortality rate in AIRD patients admitted to the ICU than reported previously, and Severity scores such as APACHE II are predictors of mortality in patients with AIRD in theICU.
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms
It is demonstrated that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals and that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry–independent mechanisms.
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals
It is shown that variations in CCL3L1 gene dose and CCR5 genotype influence HIV pathogenesis even in the presence of HAART and this work may prospectively identify subjects in whom earlier initiation of therapy is more likely to mitigate immunologic failure despite viral suppression by HAART.
CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus
The findings implicate a key role of the CCL3L1–CCR5 axis in the pathogenesis of SLE and modifies the SLE-influencing effects associated with CCR5 genotypes.
COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature
CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation1
It is suggested that by influencing a NFAT-mediated pathway that regulatesIL-2 production and IL-2-dependent events, CCR5 may play a critical role in T cell responses and constitute a viral entry-independent mechanism by which CCR 5 may influence HIV-AIDS pathogenesis.
Emerging concepts in cytomegalovirus infection following hematopoietic stem cell transplantation.
Immune correlates of protection in human invasive aspergillosis.
The most important genetic, immunological, and pharmacological factors that influence human susceptibility to Aspergillus are reviewed and the potential role of immune biomarkers in risk stratification strategies that facilitate individualized antifungal therapy/prophylaxis in immunocompromised hosts is discussed.
Production of Specific mRNA Transcripts, Usage of an Alternate Promoter, and Octamer-Binding Transcription Factors Influence the Surface Expression Levels of the HIV Coreceptor CCR5 on Primary T…
The results identify exon 1-containing transcripts, and the cis-trans factors that regulate the expression levels of these mRNA isoforms as key parameters that affect CCR5 surface expression levels, and by extension, susceptibility to HIV/AIDS among humans, and possibly, the observed interspecies differences in susceptibility to lentiviral infection.
Invasive Aspergillosis in solid‐organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice
These updated AST‐IDCOP guidelines provide information on epidemiology, diagnosis, and management of Aspergillus after organ transplantation, and the role of combination antifungals for primary therapy of IA remains controversial.