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The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
TLDR
It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection.
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Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations.
TLDR
This study represents the first detailed characterization of individual and ontogenetic venom protein profile variations in two geographical isolated B. asper populations, and highlights the necessity of using pooled venoms as a statistically representative venom for antivenom production.
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Snakebite envenoming
TLDR
Confronting snakebite envenoming at a global level demands the implementation of an integrated intervention strategy involving the WHO, the research community, antivenom manufacturers, regulatory agencies, national and regional health authorities, professional health organizations, international funding agencies, advocacy groups and civil society institutions.
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Venoms, venomics, antivenomics
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Seminal Plasma Proteins: What Role Do They Play?
Citation Rodríguez‐Martínez H, Kvist U, Ernerudh J, Sanz L, Calvete JJ. Seminal Plasma Proteins: What Role Do They Play? Am J Reprod Immunol 2011; 66 (Suppl. 1): 11–22
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Snake venom disintegrins: evolution of structure and function.
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Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal…
TLDR
The increased concentration of the neurotoxins crotoxin and crotamine in South American rattlesnake venoms strongly argues that the gain of neurotoxicity and lethal venom activities to mammals may have represented the key axis along which overall venom toxicity has evolved during Crotalus durissus invasion of South America.
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Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
TLDR
Not only soluble but also tumor cell receptor-bound pro-uPA could be efficiently cleaved by cathepsin B to generate enzymatically active two-chain uPA, which was indistinguishable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot from plasmin-generated HMW-u PA.
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Snakebite envenoming
This corrects the article DOI: 10.1038/nrdp.2017.63
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Crystal structure of the complex formed by the membrane type 1‐matrix metalloproteinase with the tissue inhibitor of metalloproteinases‐2, the soluble progelatinase A receptor
TLDR
The 2.75 Å crystal structure of the complex between the catalytic domain of human MT1‐MMP and bovine TIMP‐2 is solved and two large insertions remote from the active‐site cleft that might be important for interaction with macromolecular substrates are displayed.
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