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The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met)Expand
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Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
Abnormalities of prefrontal cortical function are prominent features of schizophrenia and have been associated with genetic risk, suggesting that susceptibility genes for schizophrenia may impact onExpand
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Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.
OBJECTIVE Numerous neuroimaging studies have examined the function of the dorsolateral prefrontal cortex in schizophrenia; although abnormalities usually are identified, it is unclear why someExpand
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Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting region of the human BDNFExpand
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Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
Monamines subserve many critical roles in the brain, and monoaminergic drugs such as amphetamine have a long history in the treatment of neuropsychiatric disorders and also as a substance of abuse.Expand
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Physiological characteristics of capacity constraints in working memory as revealed by functional MRI.
A fundamental characteristic of working memory is that its capacity to handle information is limited. While there have been many brain mapping studies of working memory, the physiological basis ofExpand
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Neurophysiological correlates of age-related changes in human motor function
BackgroundThere are well-defined and characteristic age-related deficits in motor abilities that may reflect structural and chemical changes in the aging brain. ObjectiveTo delineate age-relatedExpand
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Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.
Evidence implicates subtle neuronal pathology of the prefrontal cortex (PFC) in schizophrenia, but how this pathology is reflected in physiological neuroimaging experiments remains controversial. WeExpand
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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, weExpand
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Neural mechanisms of genetic risk for impulsivity and violence in humans.
Neurobiological factors contributing to violence in humans remain poorly understood. One approach to this question is examining allelic variation in the X-linked monoamine oxidase A (MAOA) gene,Expand
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