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Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease
We examined the effect of pioglitazone, a peroxisome proliferator‐activated receptor‐γ (PPARγ)agonistofthethiazolidinedione class, on dopaminergic nerve cell death and glial activation in theExpand
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Embryonic depletion of serotonin affects cortical development
Compelling evidence suggests that serotonin (5‐HT) is necessary for the refined organization of the cerebral cortex. Here we sought to analyse the short‐ and long‐term consequences of embryonic 5‐HTExpand
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Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro
The “club drug” 3,4-methylenedioxymethamphetamine (MDMA; also known as ecstasy) binds preferentially to and reverses the activity of the serotonin transporter, causing release of serotoninExpand
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Evolutionary Shift from Fighting to Foraging in Blind Cavefish through Changes in the Serotonin Network
BACKGROUND Within the species Astyanax mexicanus, there are several interfertile populations of river-dwelling sighted fish and cave-dwelling blind fish which have evolved morphological andExpand
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Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression
Occurring both peripherally and centrally, the kynurenine pathway (KP) - an alternative pathway to 5-HT synthesis from tryptophan (TRP) - could be of particular value to better understand the linkExpand
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Role of Serotonin via 5-HT2B Receptors in the Reinforcing Effects of MDMA in Mice
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of theExpand
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Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice
Serotonin (5-hydroxytryptamine; 5-HT) is known to increase proliferation and collagen synthesis by fibroblasts. Two receptor subtypes, 5-HT2A and 5-HT2B, have been shown to play the most importantExpand
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Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression–Boldness Syndrome
Behavioral syndromes are suites of two or more behaviors that correlate across environmental contexts. The aggression–boldness syndrome links aggression, boldness, and exploratory activity in a novelExpand
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Altered aminergic neurotransmission in the brain of organic cation transporter 3‐deficient mice
Organic cation transporters (OCTs) are carrier‐type polyspecific permeases known to participate in low‐affinity extraneuronal catecholamine uptake in peripheral tissues. OCT3 is the OCT subtype mostExpand
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Evidence for a key role of the peripheral kynurenine pathway in the modulation of anxiety- and depression-like behaviours in mice: Focus on individual differences
We previously reported that confronting mice to the Unpredictable Chronic Mild Stress procedure (UCMS) resulted in peripheral and cerebral alterations of the kynurenine pathway (KP). The presentExpand
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