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Kepler Planet-Detection Mission: Introduction and First Results
Detecting Distant Planets More than 400 planets have been detected outside the solar system, most of which have masses similar to that of the gas giant planet, Jupiter. Borucki et al. (p. 977,Expand
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Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated aExpand
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An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
A knowledge of the fate of a drug, its disposition (absorption, distribution, metabolism, and excretion, known by the acronym ADME) and pharmacokinetics (the mathematical description of the rates ofExpand
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The metabolism of aspirin in man: a population study.
The metabolism of a 900 mg oral dose of aspirin has been investigated in 129 healthy volunteers. For this purpose, the 0-12 h urine was collected and analysed for the following excretion products:Expand
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The disposition of allyl isothiocyanate in the rat and mouse.
The urine was the major route of excretion of radioactivity (50-80% of dose) following the oral administration (2.5 and 25 mg/kg body weight) of allyl[14C]isothiocyanate (AITC) to male and femaleExpand
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The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences.
The 2-arylpropionic acids are currently an important group of non-steroidal anti-inflammatory agents. They contain a chiral centre, and in vitro studies on inhibition of prostaglandin synthesis showExpand
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Ethanol teratogenesis in the C57BL/6J, DBA/2J, and A/J inbred mouse strains.
Research has shown variations in susceptibility to alcohol-related birth defects in humans. Genetic differences are one reason for this variability. This study compared three inbred mouse strains toExpand
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Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
Diclofenac is a nonsteroidal anti‐inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear. The purpose of the present study was to explore the potential roleExpand
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The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using theExpand
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The Drift of Saturn's North Polar Spot Observed by the Hubble Space Telescope
Polar projections of 50 images of Saturn at 889 nanometers and 25 images at 718 nanometers taken by the Hubble Space Telescope in November 1990, as well as 3 images at each wavelength taken in JuneExpand
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