Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
- J. Caldwell, I. Gardner, N. Swales
- BiologyToxicologic pathology (Print)
- 1 March 1995
This presentation is intended to provide an introductory overview of the life cycle of a drug in the animal body and indicates the significance of such information for a full understanding of mechanisms of action and toxicity.
The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences.
- J. Caldwell, A. Hutt, S. Fournel‐Gigleux
- Chemistry, BiologyBiochemical Pharmacology
The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
- S. A. Sangster, J. Caldwell, A. Hutt, A. Anthony, R. Smith
- ChemistryXenobiotica; the fate of foreign compounds in…
- 1 October 1987
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the…
The disposition of allyl isothiocyanate in the rat and mouse.
- M. Bollard, S. Stribbling, S. Mitchell, J. Caldwell
- BiologyFood and Chemical Toxicology
- 1 October 1997
The metabolism of aspirin in man: a population study.
- A. Hutt, J. Caldwell, R. Smith
- MedicineXenobiotica; the fate of foreign compounds in…
- 1 March 1986
The metabolism of a 900 mg oral dose of aspirin has been investigated in 129 healthy volunteers and the recovery of gentisic acid was statistically significantly greater in female subjects than in males, whilst the opposite was found for Salicyluric acid and total salicylate.
Putting chirality to work: the strategy of chiral switches
- I. Agranat, Hava Caner, J. Caldwell
- ChemistryNature reviews. Drug discovery
- 1 October 2002
Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates.
Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
Diclofenac is a nonsteroidal anti‐inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear. The purpose of the present study was to explore the potential role…
Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.
- I. Gardner, H. Wakazono, J. Caldwell
- Biology, ChemistryCarcinogenesis
- 1 September 1997
The rate of 1'-hydroxylation of methyleugenol in vitro in 13 human liver samples varied markedly (by 37-fold), with the highest activities being similar to the activity evident in control rat liver microsomes, which suggests that the risk posed by dietary ingestion of methylesugenol could vary markedly in the human population.
Metabolism of [14C]methamphetamine in man, the guinea pig and the rat
- J. Caldwell, L. Dring, R. T. Williams
- Biology, Chemistry
- 1 August 1972
The main reaction in the rat was aromatic hydroxylation, in the guinea pig demethylation and deamination, whereas in man much of the drug, possibly one-half, was excreted unchanged, and Marked species differences in the metabolism of methamphetamine were observed.