• Publications
  • Influence
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
  • R. Smith, T. Adams, +9 authors I. Sipes
  • Chemistry, Medicine
    Food and chemical toxicology : an international…
  • 1 July 2002
An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
This presentation is intended to provide an introductory overview of the life cycle of a drug in the animal body and indicates the significance of such information for a full understanding of mechanisms of action and toxicity.
The metabolism of aspirin in man: a population study.
The metabolism of a 900 mg oral dose of aspirin has been investigated in 129 healthy volunteers and the recovery of gentisic acid was statistically significantly greater in female subjects than in males, whilst the opposite was found for Salicyluric acid and total salicylate.
The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the
The disposition of allyl isothiocyanate in the rat and mouse.
Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
Diclofenac is a nonsteroidal anti‐inflammatory drug that causes rare but serious hepatotoxicity, the mechanism of which is unclear. The purpose of the present study was to explore the potential role
Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.
The rate of 1'-hydroxylation of methyleugenol in vitro in 13 human liver samples varied markedly (by 37-fold), with the highest activities being similar to the activity evident in control rat liver microsomes, which suggests that the risk posed by dietary ingestion of methylesugenol could vary markedly in the human population.
Putting chirality to work: the strategy of chiral switches
Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates.