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Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers.
Human embryonic stem (hES) cells are typically maintained on mouse embryonic fibroblast (MEF) feeders or with MEF-conditioned medium. However, these xenosupport systems greatly limit the therapeuticExpand
αB-Crystallin, an Effector of Unfolded Protein Response, Confers Anti-VEGF Resistance to Breast Cancer via Maintenance of Intracrine VEGF in Endothelial Cells
Effective inhibition of angiogenesis targeting the tumor endothelial cells requires identification of key cellular and molecular mechanisms associated with survival of vasculatures within the tumorExpand
Pigment Epithelium-derived Factor Inhibits Angiogenesis via Regulated Intracellular Proteolysis of Vascular Endothelial Growth Factor Receptor 1*
Pigment epithelium-derived factor (PEDF) has been identified as one of the most potent of endogenous negative regulators of blood vessel growth in the body. Here we report that PEDF is able toExpand
Optimal Reciprocal Reinsurance Treaties Under the Joint Survival Probability and the Joint Profitable Probability
A reinsurance treaty involves two parties, an insurer and a reinsurer. The two parties have conflicting interests. Most existing optimal reinsurance treaties only consider the interest of one party.Expand
Optimal Reinsurance from the Perspectives of both an Insurer and a Reinsurer
Optimal reinsurance from an insurer's point of view or from a reinsurer's point of view has been studied extensively in the literature. However, as two parties of a reinsurance contract, an insurerExpand
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
Vascular insufficiency and retinal ischemia precede many proliferative retinopathies and stimulate secretion of various vasoactive growth factors, including vascular endothelial growth factor (VEGF)Expand
Decreased Pigment Epithelium–Derived Factor Expression in Human Breast Cancer Progression
Purpose: The aim of this study was to correlate the expression of pigment epithelium–derived factor (PEDF), a potent endogenous antiangiogenic molecule, with severity and prognosis in breast cancer.Expand
Tcf7l2 is Tightly Controlled During Myelin Formation
Recent, studies have shown that Tcf7l2, an important transcription factor in Wnt pathway, plays critical roles in oligodendrocyte development. In this article we report a study showing that Tcf7l2 isExpand
Framework Doping of Iron in Tunnel Structure Cryptomelane
A framework doping method was proposed to dope transition-metal iron ions into the framework instead of the tunnels of 2 × 2 tunnel structure manganese octahedral molecular sieve cryptomelane. IronExpand
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellularExpand