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Autosomal recessive axonal neuropathy with neuromyotonia: a rare entity.
TLDR
The late onset of clinical myotonia essential to the diagnosis of autosomal recessive axonal neuropathy with neuromyotonia is emphasized.
Heart rate and cardiovascular protection.
TLDR
Benefits of heart rate lowering drugs, such as beta-blockers and ivabradine, in reducing overall and cardiovascular-related mortality, have been demonstrated particularly in patients with coronary heart disease and heart failure.
Differences in Hepatitis C Virus (HCV)-Specific CD8 T-Cell Phenotype during Pegylated Alpha Interferon and Ribavirin Treatment Are Related to Response to Antiviral Therapy in Patients Chronically
TLDR
A late and inefficient differentiation process of HCV-specific CD8 T cells might be associated with lack of response to treatment, and a better knowledge of the mechanisms underlying this impairment may be important for the development of new therapeutic strategies to maintain, restore, or increaseCD8 T-cell effectiveness in chronic HCV infection.
Nailfold Videocapillaroscopy Changes Are Associated With the Presence and Severity of Systemic Sclerosis–Related Interstitial Lung Disease
TLDR
Capillary loss and avascular area showed a significant association with the presence of ILD, supported by ROC curve analysis, which may reinforce a prognostic role for NVC and a physiopathology mechanism for ILD based on vascular damage.
The Immune Microenvironment in Multiple Myeloma: Friend or Foe?
TLDR
The present review will focus on the mechanisms by which myeloma cancer cells turn immune populations into their “partners in crime”, as well as promising molecules that are currently under pre-clinical tests targeting immune populations.
Immune-mediated necrotising myopathy associated with antibodies to the signal recognition particle treated with a combination of rituximab and cyclophosphamide
TLDR
A 50-year-old man presented with dysphagia and proximal muscle weakness and rituximab was started with a dramatic and progressive improvement and the disease has been kept in remission, for the last 3 years.
Patient-reported outcome instruments in clinical trials of systemic sclerosis
TLDR
The role and performance of the various patient-reported outcome instruments utilized in systemic sclerosis clinical trials, the current positioning of patient- reported outcome instruments within clinical trial endpoint models across the range of systemic sclerosis disease manifestations are considered and, where applicable, areas for future research are highlighted.
Boosting Immunity against Multiple Myeloma
TLDR
Current and future immunotherapies used in multiple myeloma with impact on bone marrow immune microenvironment cells, also known as the bone marrow immunome are reviewed.
Liquid biopsies for multiple myeloma in a time of precision medicine
TLDR
This review explores the use of the emerging field of liquid biopsies in myeloma patients considering current unmet medical needs, such as assessing the dynamic mutational landscape of Myeloma, early predictors of treatment response, and a less invasive response monitoring.
[S. Pyogenes invasive disease in a paediatric hospital: 1996-2009].
TLDR
Although the number is small, there was an increase of S. pyogenes invasive disease in the second half of the study, and microbiological investigation is essential to understand which M types or virulence factors genes are involved.
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