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Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.
We describe a new syndrome called "delayed sleep phase insomnia." Thirty of 450 patients seen for a primary insomniac complaint had the following characteristics: (1) chronic inability to fall asleepExpand
Human sleep: its duration and organization depend on its circadian phase.
Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleepExpand
Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia.
We report here the development of a brief drug-free rescheduling treatment ("chronotherapy") for Delayed Sleep Phase (DSP) insomnia, a syndrome characterized by sleep-onset insomnia with difficultyExpand
Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment
Studies were carried out on a group of six young (ages 23-30) and six older (ages 53-70) normal men who lived under conditions of temporal, but not social isolation, from three to eight weeks. DuringExpand
Timing of REM sleep is coupled to the circadian rhythm of body temperature in man.
Ten male subjects were studied for a total of 306 days on self-selected schedules. Four of them developed bedrest-activity cycle period lengths very different from 24 hr (mean = 36.8 hr) despite theExpand
Abstract— Man is the only eukaryotic organism in which it has been reported that the circadian system cannot be entrained to a 24‐h period by a simple light‐dark (LD) cycle. In this paper, weExpand
Cortisol secretion is inhibited during sleep in normal man.
In order to test the hypothesis that cortisol secretion is inhibited during sleep, six healthy young men (ages 18-24) were studied in a 4-day protocol. A baseline nocturnal sleep period was followedExpand
Timing of REM and stages 3 + 4 sleep during temporal isolation in man.
During nonentrained sleep--wake conditions in man, healthy adult subjects spontaneously develop "long" biological days (greater than 35 hr) in addition to the normal, approximately 25 hr day. TheExpand
Meal patterns in “free-running” humans
Abstract The meal patterns of men who were initiating meals for extended periods in the absence of time cues were examined. A significant, positive correlation was found between the sizes (in kcals)Expand
Cholecystokinin-induced satiety in weanling rats
Abstract Intraperitoneal injections fo the synthetic C-terminal octapeptide of cholecystokinin (CCK) into fasted 21-day-old weanling rats produced a significant suppression of intake of solid andExpand