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In Vivo Demonstration of Insulin-Receptor Defect With 123I-Labeled Insulin and Scintigraphic Scanning in Severe Insulin Resistance
Objective Insulin-receptor function in humans is usually studied in vitro on readily available cells, e.g., erythrocytes and fibroblasts. Although these cells are not metabolically important targetsExpand
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Scintigraphic distribution of 123 I labelled proinsulin, split conversion intermediates and insulin in rats
SummaryInsulin, biosynthetic human proinsulin and 2 human proinsulin conversion intermediates, des (64, 65) human proinsulin and des (31, 32) human proinsulin, were labelled with 123 I and theExpand
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Detection of autoantibodies against islet amyloid polypeptide in human serum. Lack of association with Type 1 (insulin-dependent) diabetes mellitus, or with conditions favouring amyloid deposition in
SummaryA radiobinding assay for the detection of autoantibodies against islet amyloid polypeptide was developed, analytically validated, and -in parallel with a similar assay for the detection ofExpand
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