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Paleoenvironmental model for the late Cenozoic of southwestern Amazonia: paleontology and geology
Our study provides paleontological and geological data substantiating a paleoenvironmental model for the upper Miocene-Pliocene of Southwestern Amazonia. The extensive Late Tertiary sediments of TheExpand
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Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages
Macrophages have been shown to kill Mycobacterium tuberculosis through the action of the antimicrobial peptide cathelicidin (CAMP), whose expression was shown to be induced by 1,25‐dihydroxyvitaminExpand
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LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation
Pathogenic and commensal Gram‐negative bacteria produce and release outer membrane vesicles (OMVs), which present several surface antigens and play an important role for bacterial pathogenesis. OMVsExpand
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ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
Fine-tuning pyroptosis with ESCRT-III Pyroptosis is an inflammatory form of cell death induced by select caspases downstream of inflammasome complexes. These caspases cleave gasdermin D (GSDMD),Expand
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The COPII complex and lysosomal VAMP7 determine intracellular Salmonella localization and growth
Salmonella invades epithelial cells and survives within a membrane‐bound compartment, the Salmonella‐containing vacuole (SCV). We isolated and determined the host protein composition of the SCV at 30Expand
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At the crossroads: communication of bacteria‐containing vacuoles with host organelles
Invasive bacterial pathogens are engulfed upon host cell entry in a vacuolar environment called the bacteria‐containing vacuole (BCV). BCVs directly contact with numerous host compartments, mainlyExpand
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The entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution
Salmonella enterica induces membrane ruffling and genesis of macropinosomes during its interactions with epithelial cells. This is achieved through the type three secretion system‐1, which firstExpand
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On the convergence of quadrature formulas for complex weight functions
Abstract We consider quadrature formulas for complex weights and prove their convergence for a large class of functions.
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Hierarchies of Host Factor Dynamics at the Entry Site of Shigella flexneri during Host Cell Invasion
ABSTRACT Shigella flexneri, the causative agent of bacillary dysentery, induces massive cytoskeletal rearrangement, resulting in its entry into nonphagocytic epithelial cells. The bacterium-engulfingExpand
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Sensing of invading pathogens by GBPs: At the crossroads between cell‐autonomous and innate immunity
Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect theExpand
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