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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporationExpand
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Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity
Chemotherapy often relies on cancer cell death resulting from DNA damage. The p53 tumor suppressor pathway that is an important player in DNA damage response is frequently inactivated in cancer.Expand
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High‐Throughput Live Cell Imaging of Apoptosis
Apoptosis is important for embryonic development, tissue homeostasis, and removal of cells with (potentially transforming) DNA lesions or other types of injuries. Functional genomics screensExpand
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The cancer stem cell microenvironment and anti-cancer therapy
Purpose: Tumours are composed of a heterogeneous cell population. Cancer stem cells, which make up a minor fraction of a tumour, may be the cells that initiate and sustain tumour growth. Cancer stemExpand
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Combining Doublecortin-Like Kinase Silencing and Vinca Alkaloids Results in a Synergistic Apoptotic Effect in Neuroblastoma Cells
Microtubule-destabilizing agents, such as vinca alkaloids (VAs), are part of the treatment currently applied in patients with high-risk neuroblastoma (NB). However, the development of drug resistanceExpand
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Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.
Doublecortin-like kinase-long (DCLK-long) and doublecortin-like (DCL) are two splice variants of DCLK gene. DCL and DCLK-long are microtubule-associated proteins with specific expression inExpand
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The e3 ligase aRih1 pRoTecTs againsT genoToxic sTRess by iniTiaTing a 4ehp-mediaTed mRna TRanslaTion aRResT
In an RNAi screen for (de)ubiquitinases and sumoylases modulating the apoptotic response of embryonic stem (ES) cells to DNA damage, we identify the E3 ubiquitin ligase/ ISGylase, Ariadne homologue 1Expand
Integrins and Oncogenes: Partners in Crime
Metastatic spread and acquired or intrinsic resistance to existing therapies form the two major obstacles in cancer treatment. Accumulating evidence indicates that cancer growth, metastasis, and theExpand