J. C. Izpisúa-Belmonte

Publications62
h-index40
Citations6,994
Highly Influential Citations368
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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination throughout metazoan… Expand
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Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.
Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary gland and first branchial arch. Here, we… Expand
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Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
Pitx1 (refs 1,2,3) and Pitx2 (refs 4, 5) are highly homologous, bicoid-related transcription factors. Pitx2 was initially identified as the gene responsible for the human Rieger syndrome, an… Expand
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Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.
Fibroblast Growth Factors (FGFs) are signaling molecules that are important in patterning and growth control during vertebrate limb development. Beads soaked in FGF-1, FGF-2 and FGF-4 are able to… Expand
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Fibroblast growth factors induce additional limb development from the flank of chick embryos
Fibroblast growth factors (FGFs) act as signals in the developing limb and can maintain proliferation of limb bud mesenchyme cells. Remarkably, beads soaked in FGF-1, FGF-2, or FGF-4 and placed in… Expand
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IKK1-deficient mice exhibit abnormal development of skin and skeleton.
IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant… Expand
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HOX-4 genes and the morphogenesis of mammalian genitalia.
We examined the temporal and spatial expression patterns of the homeo box HOX-4 complex genes during the morphogenesis of the genitalia of mice. The results show that only those Hox-4 genes that are… Expand
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Activation of Notch signaling pathway precedes heart regeneration in zebrafish
Several vertebrates display the ability to regenerate parts of their body after amputation. During this process, differentiated cells reenter the cell cycle and proliferate to generate a mass of… Expand
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Tbx genes and limb identity in chick embryo development.
Tbx-2, Tbx-3, Tbx-4 and Tbx-5 chick genes have been isolated and, like the mouse homologues, are expressed in the limb regions. Tbx-2 and Tbx-3 are expressed in anterior and posterior domains in… Expand
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Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.
The cloning, characterization and developmental expression patterns of two novel murine Hox genes, Hox‐4.6 and Hox‐4.7, are reported. Structural data allow us to classify the four Hox‐4 genes located… Expand
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