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Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic beta-cells as a result of theExpand
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Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.
Islet beta-cells express receptors for low density (LDL) and very low density (VLDL) lipoproteins that are internalized by receptor-mediated endocytosis. The present study examined whether thisExpand
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Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
SummaryThis study quantifies the survival of purified single rat beta cells under different culture conditions. Less than 10% of the cells survive 9 days of culture in Ham's F10 medium withoutExpand
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Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.
Thiazolidinediones are a novel class of antidiabetic drugs that reduce insulin resistance through interaction with nuclear peroxisome proliferator-activated receptor (PPAR)gamma. One of these agents,Expand
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Low Density Lipoprotein Binding and Uptake by Human and Rat Islet b Cells
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic b cells. This studyExpand
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Transplantation of Purified Islet Cells in Diabetic Rats: I. Standardization of Islet Cell Grafts
A standardized procedure was developed for the preparation of rat islet cell grafts with selected cell number and composition. After collagenase digestion of pancreases and elutriation of tissueExpand
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Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells.
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic beta cells. This studyExpand
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Low density lipoprotein binding and uptake by human and rat islet beta cells.
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic beta cells. This studyExpand
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Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride
Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic b-cells as a result of theExpand
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