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- Publications
- Influence
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
- M. Cnop, J. C. Hannaert, A. Hoorens, D. Eizirik, D. Pipeleers
- Biology, Medicine
- Diabetes
- 1 August 2001
Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic beta-cells as a result of the… Expand
Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.
- M. Cnop, J. C. Hannaert, A. Grupping, D. Pipeleers
- Medicine, Chemistry
- Endocrinology
- 1 September 2002
Islet beta-cells express receptors for low density (LDL) and very low density (VLDL) lipoproteins that are internalized by receptor-mediated endocytosis. The present study examined whether this… Expand
Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
- Z. Ling, J. C. Hannaert, D. Pipeleers
- Biology, Medicine
- Diabetologia
- 2004
SummaryThis study quantifies the survival of purified single rat beta cells under different culture conditions. Less than 10% of the cells survive 9 days of culture in Ham's F10 medium without… Expand
Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.
- M. Cnop, J. C. Hannaert, D. Pipeleers
- Biology, Medicine
- Biochemical pharmacology
- 1 April 2002
Thiazolidinediones are a novel class of antidiabetic drugs that reduce insulin resistance through interaction with nuclear peroxisome proliferator-activated receptor (PPAR)gamma. One of these agents,… Expand
Low Density Lipoprotein Binding and Uptake by Human and Rat Islet b Cells
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic b cells. This study… Expand
- 16
- 1
Transplantation of Purified Islet Cells in Diabetic Rats: I. Standardization of Islet Cell Grafts
- D. Pipeleers, M. Pipeleers-Marichal, +5 authors W. Gepts
- Biology, Medicine
- Diabetes
- 1 July 1991
A standardized procedure was developed for the preparation of rat islet cell grafts with selected cell number and composition. After collagenase digestion of pancreases and elutriation of tissue… Expand
Low Density Lipoprotein Binding and Uptake by Human and Rat Isletβ Cells.
- A. Grupping, M. Cnop, C. V. van Schravendijk, J. C. Hannaert, T. V. van Berkel, D. Pipeleers
- Chemistry, Medicine
- Endocrinology
- 1 October 1997
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic beta cells. This study… Expand
Low density lipoprotein binding and uptake by human and rat islet beta cells.
- A. Grupping, M. Cnop, C. V. van Schravendijk, J. C. Hannaert, T. V. van Berkel, D. Pipeleers
- Medicine
- Endocrinology
- 1997
Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic beta cells. This study… Expand
Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride
- Accumulation Cnop, J. C. Hannaert, A. Hoorens, D. Pipeleers
- Biology
- 2001
Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic b-cells as a result of the… Expand
- 13