• Publications
  • Influence
Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation.
TLDR
Tacrolimus provides the clinician with an effective option for patients requiring immunosuppression and, with a different tolerability and efficacy profile to cyclosporin, it will better allow the tailoring of therapy to meet the needs of individual patients.
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
TLDR
Ketorolac is a strong analgesic with a tolerability profile which resembles that of other NSAIDs when used in accordance with current dosage guidelines, this drug provides a useful alternative, or adjuvant, to opioids in patients with moderate to severe pain.
Topiramate. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy.
TLDR
Preliminary reports support the use of add-on topiramate in adults with generalised epilepsy, in childhood epilepsies and in patients with Lennox-Gastaut syndrome, as well as theUse of topIRamate monotherapy in patientsWith refractory epilepsy,topiramate can be considered an important new drug for the management of patients with refractors.
Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis.
TLDR
Available evidence suggests that secnidazole is as efficacious as other 5-nitroimidazoles drugs in the treatment of protozoal infections and bacterial vaginosis and is an attractive alternative to multiple dosage regimens with other drugs in this class.
Rifaximin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential in conditions mediated by gastrointestinal bacteria.
TLDR
Overall, rifaximin may be useful as an alternative therapy in hepatic encephalopathy but more data are needed to better define its clinical potential in infectious diarrhoea, diverticular disease and as antibacterial prophylaxis prior to colorectal surgery.
Irbesartan. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension.
TLDR
In patients with mild to moderate hypertension, once daily administration of irbesartan 150 or 300 mg, with or without adjunctive antihypertensive agents, provides effective 24-hour BP control.
Tretinoin. A review of its pharmacodynamic and pharmacokinetic properties and use in the management of acute promyelocytic leukaemia.
TLDR
Results to date indicate that the combination of tretinoin and intensive chemotherapy is more effective than chemotherapy alone and appears to improve the prognosis of newly diagnosed patients with acute promyelocytic leukaemia.
Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders.
TLDR
In view of the lack of a proven agent to limit or halt the progression of dementia in the elderly, idebenone may warrant consideration in patients with mild cognitive dysfunction on the basis of preliminary evidence of predominantly mild improvement of functional status in some patients and good tolerability.
Octreotide long-acting release (LAR). A review of its pharmacological properties and therapeutic use in the management of acromegaly.
TLDR
Octreotide continues to be the principal pharmacological option for most patients with acromegaly and the good efficacy and tolerability profile of octreotide LAR should enhance patient compliance and acceptability ofoctreotide therapy and contribute to an improvement in patient quality of life.
Transnasal butorphanol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute pain management.
TLDR
Transnasal butorphanol is a novel formulation of an established analgesic which appears suitable for the short term treatment of moderate to severe pain, especially in an ambulatory setting and is likely to provide an alternative to oral opioid analgesics, particularly in the presence of nausea or vomiting.
...
...