• Publications
  • Influence
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization.
A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water solubleExpand
  • 90
  • 1
PD 124,895 and PD 124,966, two new antitumor antibiotics.
The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124,895, is an analog of hydroxyelactocinExpand
  • 25
  • 1
Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo.
The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5 microgram/ml) and L1210 murine leukemia cells (IC50, 2.2 micrograms/ml). Acetomycin also hadExpand
  • 11
Myomycin, a new antibiotic.
The isolation and characterization of myomycin, a new broad spectrum antibiotic, are described. The isolation of myo-inositol, L-β-lysine and 3-amino-3-deoxy-D-mannose from hydrolyzates of myomycinExpand
  • 18
  • PDF
PD 114,759 and PD 115,028, novel antitumor antibiotics with phenomenal potency. I. Isolation and characterization.
The isolation of two new antibiotics, PD 114,759 and PD 115,028, exhibiting in vivo antitumor activity at extremely low doses is described. The physico-chemical properties of these sulfur-containingExpand
  • 10
Guanine-7-oxide, a novel antitumor antibiotic.
A new antibiotic, PD 113,876, was isolated from the culture broth of a Streptomyces sp. and was shown by X-ray diffraction analysis to be the N-7 oxide of guanine. This novel antimetabolite is veryExpand
  • 18
Two new trichothecenes, PD 113,325 and PD 113,326.
Two new trichothecenes, PD 113,325 and PD 113,326, were isolated and their structures were shown to be 12'-hydroxy-2'-(E)-verrucarin J (1a) and a stereoisomer of satratoxin H (3).
  • 17
PD 118,576: a new antitumor macrolide antibiotic.
The isolation and properties of PD 118,576, a new cytotoxic antibiotic obtained from the culture broth of a Streptomyces sp., are described. The structure of this compound was established by spectralExpand
  • 21