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Rational design of peptide-based HIV proteinase inhibitors.
A series of peptide derivatives based on the transition-state mimetic concept has been designed that inhibit the proteinase from the human immunodeficiency virus (HIV). The more active compounds… Expand
Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug…
- D. Warhurst, J. C. Craig, I. S. Adagu, R. K. Guy, Peter B. Madrid, Q. L. Fivelman
- Biology, Medicine
- Biochemical pharmacology
- 15 June 2007
Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin. We examine how bis 4-aminoquinoline… Expand
Dry‐Grind Process for Fuel Ethanol by Continuous Fermentation and Stripping
- Frank Taylor, M. Kurantz, Norman Goldberg, A. Mcaloon, J. C. Craig
- Environmental Science, Medicine
- Biotechnology progress
Conversion of a high‐solids saccharified corn mash to ethanol by continuous fermentation and stripping was successfully demonstrated in a pilot plant consuming 25 kg of corn per day. A mathematical… Expand
Metabolic fate of extracted glucose in normal human myocardium.
- J. Wisneski, E. Gertz, R. Neese, L. Gruenke, D. Morris, J. C. Craig
- The Journal of clinical investigation
- 1 November 1985
Glucose is an important substrate for myocardial metabolism. This study was designed to determine the effect of circulating metabolic substrates on myocardial glucose extraction and to determine the… Expand
Stereochemistry of 1-(4'-hydroxyphenyl)ethanol produced by hydroxylation of 4-ethylphenol by p-cresol methylhydroxylase.
- W. McIntire, D. Hopper, +4 authors T. Singer
- Chemistry, Medicine
- The Biochemical journal
- 1 December 1984
Enzymic hydroxylation of 4-ethylphenol by (a) Pseudomonas putida and (b) highly purified p-cresol methylhydroxylase gave optically active 1-(4'-hydroxyphenyl)-ethanol. The products were transformed… Expand
Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man.
- F. Hartmann, L. Gruenke, J. C. Craig, D. Bissell
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 May 1983
The metabolism of chlorpromazine by microsomes in vitro has been examined with extracts from normal liver and small intestinal mucosa of man and guinea pigs. A GC-MS approach has been utilized to… Expand
Dual carbon-labeled isotope experiments using D-[6-14C] glucose and L-[1,2,3-13C3] lactate: a new approach for investigating human myocardial metabolism during ischemia.
- J. Wisneski, E. Gertz, R. Neese, L. Gruenke, J. C. Craig
- Journal of the American College of Cardiology
- 1 May 1985
Simultaneous lactate production and extraction have been previously demonstrated in the myocardium in patients with coronary artery disease. To quantitate this lactate production and determine its… Expand
Vibrotactile pattern perception: extraordinary observers.
- J. C. Craig
- Psychology, Medicine
- 22 April 1977
Two sighted peopled showed a remarkable ability to perceive vibrotactile patterns generated by the Optacon, a reading aid for the blind. These individuals were able to read at very high rates, 70 to… Expand
Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid.
In nipple aspirates of breast fluid from nonpregnant healthy women, cholesterol and cholesterol epoxide levels were determined with gas-liquid chromatography and mass spectrophotometric techniques.… Expand