The estrogen-injected female mouse: new insight into the etiology of PCOS
- J. C. Chapman, S. Min, S. M. Freeh, S. D. Michael
- Biology, MedicineReproductive Biology and Endocrinology
- 18 May 2009
It is proposed that in utero exposure to excessive levels of steroids such as estrogen has a long-term effect on the ability of the thymus to produce regulatory T cells, which can lead to PCOS.
Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: An hypothesis
- J. C. Chapman, J. Polanco, Soohong Min, S. D. Michael
- BiologyReproductive Biology and Endocrinology
- 3 April 2005
Whether or not LH stimulation always results in an increase in mitochondrial HSD activity is examined by measuring the HSDactivity in microsomal and mitochondrial fractions from ovaries of pregnant mice and it was found that mitochondrial H SD activity was highest after each peak of LH.
Arginine and citrulline protect intestinal cell monolayer tight junctions from hypoxia-induced injury in piglets
- J. C. Chapman, Yuying Liu, Limin Zhu, J. M. Rhoads
- MedicinePediatric Research
- 5 October 2012
It is found that Arg and Cit were protective against HX-related damage and, via a mechanism dependent on NO donation, protected intestinal epithelial integrity.
Topology of 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase in adrenal cortex mitochondria and microsomes.
- L. Sauer, J. C. Chapman, R. Dauchy
- Biology, ChemistryEndocrinology
- 1 February 1994
The results suggest that mitochondrial 3 beta HSD is an integral inner membrane protein, that the active site faces the matrix space and is influenced by coenzyme availability, and that a regulatory site(s) faces the intermembrane space.
Proposed mechanism for sperm chromatin condensation/decondensation in the male rat
- J. C. Chapman, S. D. Michael
- BiologyReproductive Biology and Endocrinology
- 11 February 2003
It is proposed that after the loss of cytoplasm, the nuclear region of spermatozoa is directly accessible to constituents contained in the lumen of the caput epididymis, and luminal ABP attaches itself to the nuclear membrane via its binding sites, and is internalized.
The production of alpha/beta and gamma/delta double negative (DN) T-cells and their role in the maintenance of pregnancy
- J. C. Chapman, Fae M. Chapman, S. D. Michael
- Biology, MedicineReproductive Biology and Endocrinology
- 12 July 2015
It is reported that “thymocyte loss” is a normal process that occurs during the production of DN T-cells, which is unique in that it is mediated by thymic mast cells, and becomes functional following puberty.
The Differential Effect of Injecting Estradiol‐17β, Testosterone, and Hydrocortisone During the Immune Adaptive Period on the Fertility of Female Mice
- J. C. Chapman, Soohong Min, S. D. Michael, S. Kunaporn, Saureen Shah, A. Kaiki-Astara
- Biology, MedicineAmerican Journal of Reproductive Immunology
- 1 October 2001
It is proposed that injections of E2 during the immune adaptive period alter T‐cell maturation, which contributes to E2‐induced infertility.
Intracellular localization and properties of 3 beta-hydroxysteroid dehydrogenase/isomerase in the adrenal cortex.
- J. C. Chapman, L. Sauer
- Biology, ChemistryJournal of Biological Chemistry
- 25 July 1979
Nuclear androgen binding sites in the male rat. I. Unoccupied sites in the prostate.
- J. C. Chapman, A. I. Frankel
- BiologyJournal of Steroid Biochemistry
- 1 June 1984
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