• Publications
  • Influence
Presynaptic facilitation revisited: state and time dependence
  • J. Byrne, E. Kandel
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 15 January 1996
Synaptic plasticity appears to be expressed in several overlapping time domains, and the transition between very short-term facilitation and various intermediate duration phases seems to involve interactive processes between the kinases. Expand
Learning and memory : a comprehensive reference
The study of Learning and Memory is a central topic in Neuroscience and Psychology. It is also a very good example of a field that has come into maturity on all levels - in the protein chemistry andExpand
Operant Reward Learning in Aplysia: Neuronal Correlates and Mechanisms
Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded and allowed for the detailed analysis of the cellular and molecular processes underlying operant conditioning. Expand
Identification and characterization of catecholaminergic neuron B65, which initiates and modifies patterned activity in the buccal ganglia of Aplysia.
A pair of catecholaminergic interneurons, referred to as B65, in the buccal ganglia are identified and it is suggested that prolonged activity in B65 may play a role in transitioning from rejection-like to ingestion-like fictive feeding. Expand
Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia
Activation of TGF-β may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity. Expand
Levels of Serotonin in the Hemolymph of AplysiaAre Modulated by Light/Dark Cycles and Sensitization Training
It is proposed that 5- HT has a humoral role in regulation of the behavioral state of Aplysia and found that increasing levels of 5-HT in the hemolymph led to significant alterations in feeding behavior. Expand
Cellular Correlates of Long-Term Sensitization inAplysia
The results suggest that motor neurons are potential loci for storage of the memory in sensitization and emphasize the importance of plasticity at sensory–motor synapses, consistent with the idea that there are multiple sites of Plasticity distributed throughout the nervous system. Expand
Contingent-Dependent Enhancement of Rhythmic Motor Patterns: AnIn Vitro Analog of Operant Conditioning
Results suggest that the isolated buccal ganglia expressed an essential feature of operant conditioning (i.e., contingent reinforcement modified a designated operant) and that this analog ofoperant conditioning is accessible to cellular analysis. Expand
Cellular analysis of associative learning.
  • J. Byrne
  • Psychology, Medicine
  • Physiological reviews
  • 1 April 1987
Identification and characterization of neurons initiating patterned neural activity in the buccal ganglia of Aplysia.
Two patterns of neural activity were identified in excised buccal ganglia of Aplysia californica. Both are expressed in many cells, and each can be expressed independently. Using cells B4 and B5 asExpand