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Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.
OBJECTIVE The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis.
In this 24-week randomized, open-label, noninferiority trial, mycophenolate mofetil was more effective than intravenous cyclophosphamide in inducing remission of lupus nephritis and had a more favorable safety profile.
Combined oral contraceptives in women with systemic lupus erythematosus.
This study indicates that oral contraceptives do not increase the risk of flare among women with systemic lupus erythematosus whose disease is stable and is within the prespecified 9 percent margin for noninferiority.
The Effect of Combined Estrogen and Progesterone Hormone Replacement Therapy on Disease Activity in Systemic Lupus Erythematosus: A Randomized Trial
This multicenter, double-blind trial found no significant difference in flare rate between HRT and placebo groups, and health issues specific to women warrant attention and need to be confronted in patients with SLE.
Circulating endothelial cells. Biomarker of vascular disease.
Existing data on CECs are condense, possible mechanism(s) by which they may contribute to vascular pathology are summarized, and briefly compare them with progenitor cells are compared.
Classification and definition of major flares in SLE clinical trials
Because flare is one of the three major patterns of lupus activity, it will remain an important outcome measure in both longitudinal and clinical trial studies.
Cutaneous manifestations of neonatal lupus without heart block: characteristics of mothers and children enrolled in a national registry.
Future pregnancies should be monitored by serial echocardiograms, given the substantial risk for heart block and the influence of UV light, prognosis, and recurrence rates in subsequent pregnancies.
The clinical spectrum of autoimmune congenital heart block
The epidemiology, classification and management of women whose pregnancies are affected by autoimmune CHB are discussed, with a particular focus on the autoantibodies associated with autoimmuneCHB and how to test for these antibodies and diagnose this disease.