• Publications
  • Influence
3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels.
Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults andExpand
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Aortic valve disease and treatment: the need for naturally engineered solutions.
The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and arterial system. The natural anatomical geometry and microstructural complexity ensures biomechanically andExpand
  • 151
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Unique Morphology and Focal Adhesion Development of Valvular Endothelial Cells in Static and Fluid Flow Environments
Background—The influence of mechanical forces on cell function has been well documented for many different cell types. Endothelial cells native to the aortic valve may play an important role inExpand
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Transcriptional Profiles of Valvular and Vascular Endothelial Cells Reveal Phenotypic Differences: Influence of Shear Stress
Objective—The similarities between valvular and vascular lesions suggest pathological initiation mediated through endothelium, but the role of hemodynamics in valvular endothelial biology is poorlyExpand
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Transitions in Early Embryonic Atrioventricular Valvular Function Correspond With Changes in Cushion Biomechanics That Are Predictable by Tissue Composition
Endocardial cushions are critical to maintain unidirectional blood flow under constantly increasing hemodynamic forces, but the interrelationship between endocardial cushion structure and theExpand
  • 139
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Valvulogenesis: the moving target
  • J. Butcher, R. Markwald
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B…
  • 29 August 2007
Valvulogenesis is an extremely complex process by which a fragile gelatinous matrix is populated and remodelled during embryonic development into thin fibrous leaflets capable of maintainingExpand
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Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions
Introduction: Heart valve disease is an increasingly prevalent and clinically serious condition. There are no clinically effective biological diagnostics or treatment strategies. The only recourseExpand
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Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress.
Valvular endothelial cells interact with interstitial cells in a complex hemodynamic and mechanical environment to maintain leaflet tissue integrity. The precise roles of each cell type are difficultExpand
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Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells
Objective—Inflammatory activation of valve endothelium is an early phase of aortic valve disease pathogenesis, but subsequent mechanisms are poorly understood. Adult valve endothelial cells retainExpand
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Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin.
The neonatal heart undergoes normal hypertrophy or compensation to complete development and adapt to increased systolic pressures. Hypertrophy and increased neonatal wall stiffness are associatedExpand
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