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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how… Expand
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic… Expand
Multisociety guideline on reprocessing flexible GI endoscopes: 2016 update.
1,2 The beneficial role of GI endoscopy for the prevention, diagnosis, and treatment of many digestive diseases and cancer iswell established. Likemany sophisticatedmedical devices, the endoscope is… Expand
ASGE guideline for infection control during GI endoscopy.
The Quality Assurance in Endoscopy Committee of the American Society for Gastrointestinal Endoscopy (ASGE) updated and revised this document, which was originally prepared by The Standards of… Expand
Lumen-apposing covered self-expandable metal stents for short benign gastrointestinal strictures: a multicenter study.
Background and study aim Use of the fully covered self-expandable metal stent (SEMS) for benign luminal gastrointestinal (GI) stricture (BLGS) has been limited by the migration rate. The role of the… Expand
A comparative evaluation of single-balloon enteroscopy and spiral enteroscopy for patients with mid-gut disorders.
BACKGROUND Single-balloon enteroscopy (SBE) and spiral enteroscopy (SE) are recently described device-assisted techniques in endoluminal evaluation of the small bowel. No studies comparing SBE and SE… Expand
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung… Expand
EUS-guided portal vein catheterization: a promising novel approach for portal angiography and portal vein pressure measurements.
BACKGROUND Portal vein (PV) pressure measurements can provide valuable information for the management of patients with liver disease and portal hypertension. OBJECTIVE To evaluate the feasibility… Expand
How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center.
BACKGROUND Ampullary adenomas are increasingly being recognized, particularly in patients with familial adenomatous polyposis. A capsule endoscopy (CE) is routinely recommended for surveillance of… Expand
Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment.
BACKGROUND AND AIMS Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment… Expand