Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1A receptor agonist
- A. Newman-Tancredi, J. Martel, D. Cussac
- Medicine, BiologyBritish Journal of Pharmacology
- 1 January 2009
The signal transduction profile of F15599, a novel 5‐HT1A receptor agonist, is described, which suggests activation of post‐synaptic 5‐ HT1A receptors may provide enhanced therapy against depression.
Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin.
Involvement of the spinoparabrachial pathway in inflammatory nociceptive processes: A c‐Fos protein study in the awake rat
The effect of graded inflammatory stimuli (intraplantar‐carrageenan, 0.2, 1, and 6 mg/150 μl) on paw edema and c‐Fos protein expression at two levels of the spinoparabrachial pathway, the spinal cord…
7-Nitro-indazole, a selective inhibitor of neuronal nitric oxide synthese, reduces formalin evoked c-Fos expression in dorsal horn neurons of the rat spinal cord
The contribution of NMDA receptor activation to spinal c‐Fos expression in a model of inflammatory pain
The results illustrate a contribution of central NMDA receptor activation to carrageenin‐evoked spinal c‐Fos expression and a tendency towards a reduction of the number of Fos‐LI neurones in the nucleus proprius by the highest concentration of pre‐administered (+)‐HA966, but this effect did not reach significance.
Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation
Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: A quantitative ELISA study
Dose-related anti-inflammatory/analgesic effects of lornoxicam: A spinal c-Fos protein study in the rat
It is demonstrated that lORNoxicam reduces in parallel both the carrageenan-evoked oedema and spinal c-Fos expression, with clear evidence for a potent effect of low doses of lornoxicam.
The contribution of GABAB receptor-mediated events to inflammatory pain processing: carrageenan oedema and associated spinal c-Fos expression in the rat
Physiological contributions of neurokinin 1 receptor activation, and interactions with NMDA receptors, to inflammatory-evoked spinal c-Fos expression.
Laminar analysis illustrated that coadministered RP67580 and (+)-HA966 reduced the number of formalin-evoked Fos-LI neurons in the superficial and deep laminae to a similar extent byRP67580.