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A role for bone morphogenetic proteins in the induction of cardiac myogenesis.
Little is known about the molecular mechanisms that govern heart specification in vertebrates. Here we demonstrate that bone morphogenetic protein (BMP) signaling plays a central role in theExpand
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GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
We describe experiments which show that: 1) two previously identified members of the GATA family of transcription factors (both of which were originally called GATA-4) correspond to chicken cDNAs forExpand
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Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.
Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as theExpand
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Reach‐ and catchment‐scale determinants of the distribution of freshwater mussels (Bivalvia: Unionidae) in south‐eastern Michigan, U.S.A.
SUMMARY 1. We investigated the diversity and distribution of freshwater mussels at 40 sites in an agricultural catchment, the River Raisin in south-eastern Michigan, to relate mussel assemblages andExpand
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Epicardial retinoid X receptor is required for myocardial growth and coronary artery formation
Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor α (RXRα), as the systemicExpand
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The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature
Most internal organs are situated in a coelomic cavity and are covered by a mesothelium. During heart development, epicardial cells (a mesothelium) move to and over the heart, undergoExpand
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Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor.
Mouse embryos lacking the retinoic acid receptor RXRalpha properly undergo the early steps of heart development, but then fail to initiate a proliferative expansion of cardiomyocytes that normallyExpand
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A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system
The transcriptional programs that specify the distinct components of the cardiac conduction system are poorly understood, in part due to a paucity of definitive molecular markers. In the presentExpand
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