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Ki‐67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells
The nuclear Ki‐67 protein (pKi‐67) has previously been shown to be exclusively expressed in proliferating cells. As a result, antibodies against this protein are widely used as prognostic tools inExpand
HP1-β is required for development of the cerebral neocortex and neuromuscular junctions
HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their exact physiological function remains unknown. In a first attempt to elucidate the function of theseExpand
Correction: HP1gamma function is required for male germ cell survival and spermatogenesis
Background: HP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have aExpand
Epigenotype switching at the CD14 and CD209 genes during differentiation of human monocytes to dendritic cells
Using an in vitro model for the differentiation of human blood-derived monocytes into dendritic cells (DCs), we have undertaken an investigation of epigenetic changes that take place at CD14 andExpand
Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease
On-going airway inflammation is characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the key factors determining the decrease in lung function, anExpand
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing
BackgroundEndogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cellsExpand
Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15*
Mast cells (MCs) play a critical role in innate and adaptive immunity through the release of cytokines, chemokines, lipid mediators, biogenic amines, and proteases. We recently showed that theExpand
HP1γ function is required for male germ cell survival and spermatogenesis
BackgroundHP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have aExpand
A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects
ABSTRACTMammals have three HP1 protein isotypes HP1β (CBX1), HP1γ (CBX3) and HP1α (CBX5) that are encoded by the corresponding genes Cbx1, Cbx3 and Cbx5. Recent work has shown that reduction of CBX3Expand
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