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High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma.
BACKGROUND High-dose therapy with supporting autologous stem-cell transplantation remains a controversial treatment for cancer. In multiple myeloma, first-line regimens incorporating high-dose… Expand
Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial
BACKGROUND MRI might improve diagnosis of breast cancer, reducing rates of reoperation. We assessed the clinical efficacy of contrast-enhanced MRI in women with primary breast cancer. METHODS We… Expand
Summary of product characteristics
4 CLINICAL PARTICULARS 4.1 Therapeutic Indications Trimetazidine is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately… Expand
Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
- N. Patsoukis, J. Brown, V. Petkova, Fang Liu, L. Li, V. Boussiotis
- Biology, Medicine
- Science Signaling
- 26 June 2012
The inhibitory receptor PD-1 blocks T cell proliferation by preventing cells from leaving the G1 phase of the cell cycle. PD-1 Inhibits the Cell Cycle Machinery Effector T cells are stimulated… Expand
Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial.
BACKGROUND The addition of bevacizumab to chemotherapy improves progression-free survival in metastatic breast cancer and pathological complete response rates in the neoadjuvant setting.… Expand
Bladder and Sexual Function Following Resection for Rectal Cancer in a Randomized Clinical Trial of Laparoscopic Versus Open Technique
Minimization--reducing predictability for multi-centre trials whilst retaining balance within centre.
- S. Brown, H. Thorpe, K. Hawkins, J. Brown
- Computer Science, Medicine
- Statistics in medicine
- 30 December 2005
Minimization is often used to assign patients to treatment groups to ensure good balance in patient numbers within centre and other prognostic factors. Expand
Evaluating Participatory Initiatives in South Africa
- J. Brown
- 18 April 2014
The participatory model of management for natural resources, particularly water, rapidly became a global phenomenon in the early part of the 21st century. In many developing and transition countries,… Expand
Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study.
- D. Aronson, J. Schnater, +9 authors A. Vos
- Journal of clinical oncology : official journal…
- 20 February 2005
PURPOSE Preoperative staging (pretreatment extent of disease [PRETEXT]) was developed for the first prospective liver tumor study by the International Society of Pediatric Oncology (SIOPEL-1 study;… Expand
Integrating Patient Reported Outcomes With Clinical Cancer Registry Data: A Feasibility Study of the Electronic Patient-Reported Outcomes From Cancer Survivors (ePOCS) System
Background Routine measurement of Patient Reported Outcomes (PROs) linked with clinical data across the patient pathway is increasingly important for informing future care planning. The innovative… Expand