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The sulfur-containing amino acids: an overview.
Methionine, cysteine, homocysteine, and taurine are the 4 common sulfur-containing amino acids, but only the first 2 are incorporated into proteins. Sulfur belongs to the same group in the periodicExpand
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Branched-chain amino acids: enzyme and substrate regulation.
The three branched-chain amino acids (BCAAs) are the most hydrophobic of the amino acids and play crucial roles in determining the structures of globular proteins as well as the interaction of theExpand
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Is it time to reevaluate methyl balance in humans?
S-Adenosylmethionine (AdoMet) is the major biological methyl donor. AdoMet's methyl group arises both from the diet (eg, methionine, choline, and betaine) and from de novo synthesis by the process ofExpand
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The metabolic burden of creatine synthesis
Creatine synthesis is required in adult animals to replace creatine that is spontaneously converted to creatinine and excreted in the urine. Additionally, in growing animals it is necessary toExpand
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Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans.
Significant gaps remain in our knowledge of the pathways of amino acid catabolism in humans. Further quantitative data describing amino acid metabolism in the kidney are especially needed as areExpand
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Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.
S-adenosylmethionine, formed by the adenylation of methionine via S-adenosylmethionine synthase, is the methyl donor in virtually all known biological methylations. These methylation reactionsExpand
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Creatine: endogenous metabolite, dietary, and therapeutic supplement.
Creatine and phosphocreatine serve not only as an intracellular buffer for adenosine triphosphate, but also as an energy shuttle for the movement of high-energy phosphates from mitochondrial sites ofExpand
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Interorgan amino acid transport and its regulation.
  • J. Brosnan
  • Biology, Medicine
  • The Journal of nutrition
  • 1 June 2003
Interorgan amino acid transport is a highly active and regulated process that provides amino acids to all tissues of the body, both for protein synthesis and to enable amino acids to be used forExpand
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Renal arginine synthesis: studies in vitro and in vivo.
Renal arginine synthesis is a major endogenous source of arginine. Argininosuccinate lyase occurs almost exclusively in kidney cortex. In studies with isolated renal cortical tubules, we observedExpand
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Methyl balance and transmethylation fluxes in humans.
Various questions have been raised about labile methyl balance and total transmethylation fluxes, and further discussion has been encouraged. This report reviews and discusses some of the relevantExpand
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