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Solution NMR Studies of the Aβ(1−40) and Aβ(1−42) Peptides Establish that the Met35 Oxidation State Affects the Mechanism of Amyloid Formation
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation of the 40-residue Aβ(1−40) and 42-residue Aβ(1−42) peptides into amyloid plaques. The structural changes… Expand
ON MACHINE-LEARNED CLASSIFICATION OF VARIABLE STARS WITH SPARSE AND NOISY TIME-SERIES DATA
With the coming data deluge from synoptic surveys, there is a need for frameworks that can quickly and automatically produce calibrated classification probabilities for newly observed variables based… Expand
AN ANCIENT EXTRASOLAR SYSTEM WITH FIVE SUB-EARTH-SIZE PLANETS
The chemical composition of stars hosting small exoplanets (with radii less than four Earth radii) appears to be more diverse than that of gas-giant hosts, which tend to be metal-rich. This implies… Expand
Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation.
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation of the 40-residue A beta(1-40) and 42-residue A beta(1-42) peptides into amyloid plaques. The structural… Expand
RUPRECHT 147: THE OLDEST NEARBY OPEN CLUSTER AS A NEW BENCHMARK FOR STELLAR ASTROPHYSICS
Ruprecht 147 is a hitherto unappreciated open cluster that holds great promise as a standard in fundamental stellar astrophysics. We have conducted a radial velocity survey of astrometric candidates… Expand
Retired A Stars and Their Companions. VI. A Pair of Interacting Exoplanet Pairs Around the Subgiants 24 Sextanis and HD 200964
We report radial velocity (RV) measurements of the G-type subgiants 24 Sextanis (= HD 90043) and HD 200964. Both are massive, evolved stars that exhibit periodic variations due to the presence of a… Expand
The structure of yeast enolase at 2.25-A resolution. An 8-fold beta + alpha-barrel with a novel beta beta alpha alpha (beta alpha)6 topology.
The three-dimensional structure of yeast enolase has been determined by the multiple isomorphous replacement method followed by the solvent flattening technique. A polypeptide model, corresponding… Expand
Mechanism of enolase: the crystal structure of asymmetric dimer enolase-2-phospho-D-glycerate/enolase-phosphoenolpyruvate at 2.0 A resolution.
- E. Zhang, J. Brewer, W. Minor, L. Carreira, L. Lebioda
- Chemistry, Medicine
- 14 October 1997
Enolase, a glycolytic enzyme that catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to form phosphoenolpyruvate (PEP), is a homodimer in all eukaryotes and many prokaryotes. Here, we report… Expand
A conserved region in the σ54‐dependent activator DctD is involved in both binding to RNA polymerase and coupling ATP hydrolysis to activation
Rhizobium melioti DctD activates transcription from the dctA promoter by catalysing the isomerization of closed complexes between σ54‐RNA polymerase holoenzyme and the promoter to open complexes.… Expand