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Specificity and regulation of a synaptic vesicle docking complex
Synaptic vesicles are proposed to dock at the presynaptic plasma membrane through the interaction of two integral membrane proteins of synaptic vesicles, VAMP and synaptotagmin, and two plasmaExpand
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The Cysteine String Secretory Vesicle Protein Activates Hsc70 ATPase*
Cysteine string protein (CSP) is a 34 kDa secretory vesicle protein bearing a “J-domain” as well as a palmitoylated cysteine-rich “string” region used for membrane attachment. Mutation of the CSPExpand
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Regulation of the synthesis, processing and translocation of lipoprotein lipase.
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Cysteine string protein (CSP) is an insulin secretory granule‐associated protein regulating β‐cell exocytosis
Cysteine string proteins (CSPs) are novel synaptic vesicle‐associated protein components characterized by an N‐terminal J‐domain and a central palmitoylated string of cysteine residues. The cellularExpand
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G Protein Modulation of N-type Calcium Channels Is Facilitated by Physical Interactions between Syntaxin 1A and Gβγ*
The direct modulation of N-type calcium channels by G protein βγ subunits is considered a key factor in the regulation of neurotransmission. Some of the molecular determinants that govern the bindingExpand
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Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels
We have identified a novel interaction between huntingtin (htt) and N-type calcium channels, a channel key in coupling calcium influx with synaptic vesicle exocytosis. Htt is a widely expressedExpand
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The cysteine string protein multimeric complex.
Cysteine string protein (CSPalpha) is a member of the cellular folding machinery that is located on regulated secretory vesicles. We have previously shown that CSPalpha in association with Hsc70Expand
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Cysteine String Protein (CSP) Inhibition of N-type Calcium Channels Is Blocked by Mutant Huntingtin*
Cysteine string protein (CSP), a 34-kDa molecular chaperone, is expressed on synaptic vesicles in neurons and on secretory vesicles in endocrine, neuroendocrine, and exocrine cells. CSP can be foundExpand
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Syntaxin 1A Co‐Associates with Native Rat Brain and Cloned Large Conductance, Calcium‐Activated Potassium Channels in situ
Large conductance, calcium‐activated potassium channels (BKCa channels) are regulated by several distinct mechanisms, including phosphorylation/dephosphorylation events and protein‐proteinExpand
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Characterization of the G alpha(s) regulator cysteine string protein.
Cysteine string protein (CSP) is an abundant regulated secretory vesicle protein that is composed of a string of cysteine residues, a linker domain, and an N-terminal J domain characteristic of theExpand
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