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Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility. Expand
Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index
TLDR
A quantitative donor risk index was developed using national data from 1998 to 2002 to assess the risk of donor liver graft failure using seven donor characteristics that independently predicted significantly increased risk of graft failure. Expand
Discovery and Refinement of Loci Associated with Lipid Levels
TLDR
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Expand
New genetic loci link adipose and insulin biology to body fat distribution
TLDR
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Expand
Nonadherence in hemodialysis: associations with mortality, hospitalization, and practice patterns in the DOPPS.
TLDR
Nonadherence was associated with increased mortality risk (skipping treatment, excessive IDWG, and high phosphate) and with hospitalization risk (kipping, high phosphate). Expand
US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States.
Author(s): Saran, Rajiv; Li, Yi; Robinson, Bruce; Ayanian, John; Balkrishnan, Rajesh; Bragg-Gresham, Jennifer; Chen, Joline TL; Cope, Elizabeth; Gipson, Debbie; He, Kevin; Herman, William; Heung,Expand
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
TLDR
The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes. Expand
Association of comorbid conditions and mortality in hemodialysis patients in Europe, Japan, and the United States: the Dialysis Outcomes and Practice Patterns Study (DOPPS).
TLDR
Variability in demographic and comorbid conditions (as identified by dialysis facilities) explains only part of the differences in mortality between dialysis centers, both for comparisons made across continents and within the US. Expand
Common variants associated with plasma triglycerides and risk for coronary artery disease
TLDR
It is suggested that triglyceride-rich lipoproteins causally influence risk for CAD, and the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. Expand
Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: the DOPPS.
TLDR
There are differences in HCV prevalence and rate of seroconversion at the country and the hemodialysis facility level and the observed variation suggests opportunities for improved HCV outcomes. Expand
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