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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
TLDR
The expression of apolipoprotein E,E(LDL) receptors by brain cells and the presence of apoE- and apoA-I-containing lipoproteins in CSF suggest that the central nervous system has a mechanism for lipid transport and cholesterol homeostasis similar to that of other tissues. Expand
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
TLDR
The phenotypic resemblance of these cells to fibroblasts supports the hypothesis that lipocytes are a major source of collagen in pathologic fibrosis and may be precursors of the fibroblast-like cells observed in liver injury. Expand
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.
TLDR
Analysis of cells of the central and peripheral nervous systems of the rat suggests that apo E has an important, previously unsuspected role in the physiology of nervous tissue. Expand
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
TLDR
In all 29 patients that were studied, the postoperative serum apoE phenotype of the recipient, as assessed by isoelectric focusing, converted virtually completely to that of the donor, providing evidence that greater than 90% of the apo E in the plasma is synthesized by the liver, and indicating that most of the ApoE in CSF cannot be derived from the plasma pool and therefore must be synthesized locally. Expand
Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture.
TLDR
It is demonstrated that the acquisition by lipocytes of a smooth muscle marker accompanies their 'activation', and is consistent with the hypothesis that lipocytes transform to myofibroblasts during liver injury. Expand
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.
TLDR
Primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro and it was found that lipoproteins contained in these cells may function to redistribute lipid and regulate cholesterol homeostasis within the brain. Expand
A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.
TLDR
The results demonstrate that the regenerating peripheral nerve possesses the components of a cholesterol transfer mechanism, and the sequence of events suggests that this mechanism supplies the cholesterol required for rapid membrane biogenesis during axon regeneration and remyelination. Expand
Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture
TLDR
A reproducible method is established for the isolation and primary culture of human lipocytes and Kupffer cells from wedge sections of normal human liver and their properties in primary culture are examined. Expand
Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix.
TLDR
Results show that the extracellular matrix can modulate matrix protein production by lipocytes and imply that, in early hepatic inflammation, changes in the hepatic subendothelial matrix may underlie stimulation of lipocyte matrix production and progression of the fibrotic process. Expand
Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells
TLDR
The data indicate that specific sinusoidal endothelial cells, not the macrophages of the reticuloendothelial system, are primarily responsible for the removal of these modified lipoproteins from the circulation in vivo. Expand
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