• Publications
  • Influence
Development and validation of a pediatric Crohn's disease activity index.
TLDR
It is proposed that the PCDAI could be used in multicenter projects to facilitate patient stratification by disease severity and that longitudinalPCDAI scores might provide a numerical measure of response to therapeutic regimens.
Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC‐1] and Byler syndrome): Evidence for heterogeneity
TLDR
Examination of haplotypes in siblings with ByS in two unrelated non‐Amish families showed that the gene(s) responsible for their disorder did not lie in the PFIC‐1 candidate region, and genetic analysis and light microscopy and TEM of liver may help distinguish PF IC‐1 from other forms of ByS.
Chronic Abdominal Pain In Children: a Technical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
TLDR
Although children with chronic abdominal pain and their parents are more often anxious or depressed, the presence of anxiety, depression, behavior problems or recent negative life events does not distinguish between functional and organic abdominal pain.
Relationship of Common Laboratory Parameters to the Activity of Crohn's Disease in Children
TLDR
No single laboratory test is adequate to reflect disease activity in all patients, and future work will need to identify additional laboratory measures to reflect the inflammatory process and serve as important adjuncts in the assessment of disease activity.
Guidelines for Evaluation and Treatment of Gastroesophageal Reflux in Infants and Children: Recommendations of the North American Society for Pediatric Gastroenterology and Nutrition
TLDR
The GER Guideline Committee of the North American Society for Pediatric Gastroenterology and Nutrition has formulated a clinical practice guideline for the management of pediatric GER, and the American Academy of Pediatrics has also endorsed these recommendations.
Liver transplantation for the treatment of urea cycle disorders
TLDR
It is concluded from the experience that liver transplantation can be an effective treatment for children with urea cycle defects and whether the quality of life is improved and medical expense is reduced by transplantation.
Comparison of airway responses following tracheal or esophageal acidification in the cat.
TLDR
The results support the view that microaspiration into the trachea is a much more likely mechanism for bronchospasm associated with gastroesophageal reflux than simple acid reflux into the esophagus.
Chronic Abdominal Pain in Children: A Clinical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition: American Academy
TLDR
This clinical report provides guidance for the clinician in the evaluation and treatment of children with chronic abdominal pain and draws conclusions based on the evidence reviewed in the technical report and on consensus achieved among subcommittee members.
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