• Publications
  • Influence
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
TLDR
Disruption of the estrogen receptor in humans need not be lethal and is important for bone maturation and mineralization in men as well as women.
Effect of testosterone and estradiol in a man with aromatase deficiency.
TLDR
The responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of cytochrome P-450 aromatase suggest a crucial role of estrogen in skeletal maturation.
Molecular basis of endometrial cancer
TLDR
This research attacked the mode of action of tumor suppressor genes by attacking the “good” and “bad” genes, finding that the former improved the chances of survival and the latter decreased the likelihood of survival.
A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer
TLDR
The combination of erlotinib and bevacizumab was well-tolerated but had limited activity in unselected patients with previously treated MBC, and biomarkers are needed to identify those MBC patients likely to respond to anti-EGFR/HER1 plus anti-VEGF therapy.
The molecular genetics of endometrial carcinoma.
Inherited predisposition to breast and ovarian cancer.
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer
TLDR
Results indicate that sorafenib triggers a mechanistic MAPK/JNK-dependent early protective autophagic response in EC cells, providing an adaptive response to therapeutic stress, and highlights a new strategy for therapeutic intervention in recurrent EC.
BRCA: the breast, ovarian, and other cancer genes.
  • J. Boyd
  • Medicine
    Gynecologic oncology
  • 1 March 2001
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