J. Bouwstra

Publications431
h-index79
Citations21,455
Highly Influential Citations437
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Structure of the skin barrier and its modulation by vesicular formulations.
TLDR
In order to unravel the mechanisms involved in increasing the drug transport across the skin, information on the effect of vesicles on drug permeation rate, the permeation pathway and perturbations of the skin ultrastructure is of importance. Expand
In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
Abstract A number of natural or partially modified polymers was screened for mucoadhesive properties by routinely measuring the force of detachment for swollen polymer films from pig intestinal… Expand
The skin barrier in healthy and diseased state.
TLDR
The information on the role various lipid classes play in lipid phase behavior has been used to interpret the changes in lipid organization and barrier properties of diseased skin. Expand
Lipid organization in pig stratum corneum.
TLDR
The results led us to conclude that the intercellular lipids in the stratum corneum are organized in at least two different lamellar structures with repeat distances of 6 and 13.2 nm. Expand
Structural investigations of human stratum corneum by small-angle X-ray scattering.
TLDR
The structure of human stratum corneum was investigated with small-angle X-ray scattering (SAXS) and it is concluded that in the original curve the lipids are arranged in two unit cells with repeat distances of 6.4 nm and 13. Expand
The lipid organisation in the skin barrier.
TLDR
A short description of the lipid organisation in normal human stratum corneum will be given, after which the role the main lipid classes play in the stratum Corneum lipid organisation will be described and a new model, the "sandwich model", will be proposed that describe the localisation of the fluid phases in the Stratum cor pneumonia. Expand
The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C.
TLDR
The results indicate the key role vitamin C plays in the formation of stratum corneum barrier lipids and the improvement of the lipid profile was accompanied by a marked improved of the barrier formation. Expand
The important role of stratum corneum lipids for the cutaneous barrier function.
TLDR
An overview of the reported SC lipid composition and organization mainly focusing on healthy and diseased human skin is provided and an overview on the relation between lipid modulations and the impaired skin barrier function is provided. Expand
Modes of action of terpene penetration enhancers in human skin; Differential scanning calorimetry, small-angle X-ray diffraction and enhancer uptake studies
The mechanisms through which the terpenes, d-limonene, 1–8-cineole and nerolidol, increase the permeability of human stratum corneum (s.c.) and the mechanisms underlying propylene glycol (PG)/terpene… Expand
Structure of human stratum corneum as a function of temperature and hydration a wide-angle X-ray diffraction study
Wide-angle X-ray diffraction measurements were performed as a function of temperature and hydration on human stratum corneum. Reflections located close to the beam stop (d > 1 nm) could be explained… Expand
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