Structure of the skin barrier and its modulation by vesicular formulations.
The skin barrier in healthy and diseased state.
In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
Structural investigations of human stratum corneum by small-angle X-ray scattering.
- J. Bouwstra, G. Gooris, J. A. van der Spek, W. Bras
- Materials ScienceJournal of Investigative Dermatology
- 1 December 1991
The structure of human stratum corneum was investigated with small-angle X-ray scattering (SAXS) and it is concluded that in the original curve the lipids are arranged in two unit cells with repeat distances of 6.4 nm and 13.
The important role of stratum corneum lipids for the cutaneous barrier function.
Microneedle technologies for (trans)dermal drug and vaccine delivery.
Lipid organization in pig stratum corneum.
The results led us to conclude that the intercellular lipids in the stratum corneum are organized in at least two different lamellar structures with repeat distances of 6 and 13.2 nm.
In vivo assessment of safety of microneedle arrays in human skin.
Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S]
It is demonstrated for the first time that changes in ceramide chain length and lipid organization are directly correlated with the skin barrier defects in nonlesional skin of AE patients and will provide a new therapeutic entry in therapy and prevention of AE.