J. Borrell

Publications147
h-index20
Citations1,636
Highly Influential Citations10
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ALK and ROS1 as a joint target for the treatment of lung cancer: a review.
Rearrangements of the anaplastic lymphoma kinase (ALK) have been described in multiple malignancies, including non-small cell lung cancer (NSCLC). ALK fusions have gain of function properties while… Expand
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Porphycenes: facts and prospects in photodynamic therapy of cancer.
The photodynamic process induces cell damage and death by the combined effect of a photosensitizer (PS), visible light, and molecular oxygen, which generate singlet oxygen ((1)O(2)) and other… Expand
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A convenient synthesis of 13N-labelled azo compounds: a new route for the preparation of amyloid imaging PET probes.
In the present paper, a fast and automated method for the synthesis of (13)N-labelled azo compounds is reported for the first time. The labelling strategy is based on trapping [(13)N]NO(2)(-) in an… Expand
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Synthesis of 13N‐labelled radiotracers by using microfluidic technology
Microfluidics has recently emerged as a useful alternative to traditional methods for the preparation of radiotracers labelled with positron emitters. Up to date, microfluidics technology has been… Expand
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Fully automated synthesis of 13N-labeled nitrosothiols
Abstract In the present Letter, a fast, automated, and reproducible method for the synthesis of S -[ 13 N]nitrosothiols is reported. The labeling strategy is based on trapping [ 13 N ] NO 2 - in an… Expand
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Efficient system for the preparation of [13N]labeled nitrosamines.
In the present Letter, a fast and reproducible method for the synthesis of N-[(13)N]nitrosamines is reported. The labeling strategy is based on trapping [(13)N]NO2- in an anion exchange resin. The… Expand
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Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma
BackgroundPharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical… Expand
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Regioselective symmetrical bromination of protected 2,2'-biimidazole
Treatment of the benzyl and (trimethylsilylethoxymethyl) SEM protected 2,2′-biimidazoles, 2a and 2b, with 2 equivalents of N-bromosuccinimide (NBS) allows obtaining the 5,5′-dibromo and 4,4′-dibromo… Expand
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Two-photon absorption in tetraphenylporphycenes: are porphycenes better candidates than porphyrins for providing optimal optical properties for two-photon photodynamic therapy?
Porphycenes are structural isomers of porphyrins that have many unique properties and features. In the present work, the resonant two-photon absorption of 2,7,12,17-tetraphenylporphycene (TPPo) and… Expand
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Enantioresolution of Substituted 2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles on Macrocyclic Antibiotic and Cyclodextrin Stationary Phases
Abstract Nine different 4−, or 5− substituted racemic pyridones were synthesized and resolved by reversed phase LC. Seven of the compounds showed complete or partial resolution on the vancomycin… Expand
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