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Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction
- J. L. Burg, C. M. Grover, P. Pouletty, J. Boothroyd
- Biology, MedicineJournal of clinical microbiology
- 1 August 1989
A combination of sensitivity and specificity should make detection of the B1 gene based on polymerase chain reaction amplification a very useful method for diagnosis of toxoplasmosis both in immunocompromised hosts and in congenitally infected fetuses.
Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors
- A. Vyas, Seon-Kyeong Kim, Nicholas J. Giacomini, J. Boothroyd, R. Sapolsky
- Biology, PsychologyProceedings of the National Academy of Sciences
- 10 April 2007
This study provides a strong argument in support of the behavioral manipulation hypothesis, by closely examining other types of behavioral patterns that were predicted to be altered and showing that the behavioral effect of chronic Toxoplasma infection is highly specific.
Virulent strains of Toxoplasma gondii comprise a single clonal lineage
Analysis of 28 strains from a variety of hosts on five continents suggests that virulent strains of T. gondii originated from a single lineage which has remained genetically homogeneous despite being globally widespread, and despite the ability of this organism to reproduce sexually.
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
This work uses genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16, and provides a new mechanism for how an intracellular eukaryotic pathogen can interact with its host.
Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.
- J. L. Burg, D. Perelman, L. Kasper, P. Ware, J. Boothroyd
- BiologyJournal of immunology
- 15 November 1988
The complete sequence of P30, the major surface Ag of the protozoan parasite, Toxoplasma gondii, has been deduced through the cloning and analysis of its gene and the apparent 5' and 3' ends of the P30 mRNA transcript are identified.
Identification of the Moving Junction Complex of Toxoplasma gondii: A Collaboration between Distinct Secretory Organelles
Surprisingly, three new proteins derived from micronemes, but from the anterior secretory organelles known as rhoptries and specifically, for at least two, from the neck portion of these club-shaped structures are found throughout the Apicomplexa.
Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote.
- J. Bangs, L. Uyetake, M. Brickman, A. Balber, J. Boothroyd
- BiologyJournal of cell science
- 1 August 1993
Using the polymerase chain reaction with degenerate primers, three new members of the hsp70 gene family of Trypanosoma brucei have been identified. A genomic clone of one of these, gA, has been fully…
Lytic Cycle of Toxoplasma gondii
The current knowledge of how the asexual tachyzoite stage of Toxoplasma attaches to, invades, replicates in, and exits the host cell is described, which is closely analogous to the way in which viruses reproduce.
Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis
Results suggest that secreted kinases unique to the Apicomplexa are crucial in the host-pathogen interaction.
Unusual abundance of atypical strains associated with human ocular toxoplasmosis.
- M. Grigg, J. Ganatra, J. Boothroyd, T. Margolis
- Biology, MedicineThe Journal of infectious diseases
- 1 September 2001
The unusual bias toward type I and/or recombinant genotypes bearing the SAG1 type I allele associated with mouse virulence in immunocompetent adults has important implications for the epidemiology and efficacious treatment of ocular toxoplasmosis.