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  • Influence
Carrier effects on biological activity of amphotericin B.
Amphotericin B (AmB), the drug of choice for the treatment of most systemic fungal infections, is marketed under the trademark Fungizone, as an AmB-deoxycholate complex suitable for intravenousExpand
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How do the polyene macrolide antibiotics affect the cellular membrane properties?
  • J. Bolard
  • Medicine, Chemistry
  • Biochimica et biophysica acta
  • 1 December 1986
In the 1970's great strides were made in understanding the mechanism of action of amphotericin B and nystatin: the formation of transmembrane pores was clearly demonstrated in planar lipidExpand
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Effects of aggregation and solvent on the toxicity of amphotericin B to human erythrocytes.
In aqueous suspensions of amphotericin B (AmB), a polyene antibiotic and antifungal agent, three forms of AmB coexist: monomers, water-soluble oligomers, and non-water-soluble aggregates. TheExpand
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Amphotericin B: new life for an old drug.
Interest in amphotericin B has undergone a renaissance of sorts over the past few years despite the advent of the newer less-toxic azole antifungal drugs. This is, in part, owing to the unfortunateExpand
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One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtainedExpand
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Interaction between phospholipid bilayer membranes and the polyene antibiotic amphotericin B: lipid state and cholesterol content dependence.
The interaction between amphotericin B and egg yolk phosphatidylcholine, dimyristoyl (DMPC) and dipalmitoyl phosphatidylcholine (DPPC) phospholipid bilayer vesicles has been monitored by the circularExpand
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SNARF-1 as an intracellular pH indicator in laser microspectrofluorometry: a critical assessment.
The use of SNARF-1-AM (seminaphtorhodafluor-1-acetoxymethylester) to measure the internal pH of a single living cell by laser microspectrofluorometry has been analyzed with a lymphocyte murine B cellExpand
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Nuclear pH gradient in mammalian cells revealed by laser microspectrofluorimetry.
Intracellular pH has been measured by laser microspectrofluorimetry, using the pH-sensitive dyes SNARF-1, SNARF-calcein and SNARF-1-dextran. By this technique it was possible to accurately determineExpand
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Physico-chemical properties of the heat-induced 'superaggregates' of amphotericin B.
The aggregation state of amphotericin B (AmB) was previously reported to modulate its therapeutic efficiency. As a preliminary study to test the biological effects of 'superaggregates' generated byExpand
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Delivery systems for antisense oligonucleotides.
In vitro, the efficacy of the antisense approach is strongly increased by systems delivering oligodeoxyribonucleotides (ODNs) to cells. Up to now, most of the developed vectors favor ODN entrance byExpand
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