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Kinetics of hydrolysis of barbituric acid derivatives.
- E. R. Garrett, J. Bojarşki, G. Yakatan
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 August 1971
The neutral and alkaline hydrolyses of barbituric acid and some of its substituted derivatives were followed spectrophotometrically. The rate‐pH profiles for all of the 5,5‐disubstituted barbiturates… Expand
Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via β-Cyclodextrin Inclusion Complexes
Abstract β-Cyclodextrin as the chiral mobile phase component was used for resolution of mephenytoin and some barbiturates (antidepressant drugs) into enantiomers on LiChrosorb RP 18 column. The… Expand
Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase…
Abstract Using LiChrosorb RP-18 as the stationary phase, systematic studies were performed on the changes in the capacity factors of a series of hydantoin and barbituric acid derivatives (including… Expand
Direct liquid chromatographic separation of enantiomers on immobilized protein stationary phases. VI. Optical resolution of a series of racemic barbiturates: studies of substituent and mobile phase…
Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated beta-cyclodextrins.
The correlation between the capacity factors of enantiomers of chiral barbiturates and the concentrations of beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin and… Expand
Quasi-column chromatography of barbituric acid derivatives II. Separation on Non-polar adsorbents using binary water-organic solvent mixtures as the mobile phase
SummaryTwenty barbituric acid derivatives having four different types of substitution were separated in TLC-S chambers. Using non-polar adsorbents (silanized silica gel or silica gel coated with… Expand
(R)-(-)-10-methyl-11-hydroxyaporphine: a highly selective serotonergic agonist.
- J. Cannon, P. Mohan, +5 authors T. Chatterjee
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 February 1988
Prior work in these laboratories identified (+/-)-5-hydroxy-6-methyl-2- (di-n-propylamino)tetralin as a dopaminergic agonist prodrug. The ortho methyl hydroxy aromatic substitution pattern in this… Expand
Whats New in Chromatographic Enantioseparations
Progress in different areas of enantioselective chromatography and its applications in last years (2002-2003) is reviewed. Special attention is devoted to chromatographic enantioseparations of… Expand