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Kinetics of hydrolysis of barbituric acid derivatives.
The neutral and alkaline hydrolyses of barbituric acid and some of its substituted derivatives were followed spectrophotometrically. The rate‐pH profiles for all of the 5,5‐disubstituted barbituratesExpand
Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via β-Cyclodextrin Inclusion Complexes
Abstract β-Cyclodextrin as the chiral mobile phase component was used for resolution of mephenytoin and some barbiturates (antidepressant drugs) into enantiomers on LiChrosorb RP 18 column. TheExpand
Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase
Abstract Using LiChrosorb RP-18 as the stationary phase, systematic studies were performed on the changes in the capacity factors of a series of hydantoin and barbituric acid derivatives (includingExpand
Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated beta-cyclodextrins.
The correlation between the capacity factors of enantiomers of chiral barbiturates and the concentrations of beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin andExpand
Quasi-column chromatography of barbituric acid derivatives II. Separation on Non-polar adsorbents using binary water-organic solvent mixtures as the mobile phase
SummaryTwenty barbituric acid derivatives having four different types of substitution were separated in TLC-S chambers. Using non-polar adsorbents (silanized silica gel or silica gel coated withExpand
(R)-(-)-10-methyl-11-hydroxyaporphine: a highly selective serotonergic agonist.
Prior work in these laboratories identified (+/-)-5-hydroxy-6-methyl-2- (di-n-propylamino)tetralin as a dopaminergic agonist prodrug. The ortho methyl hydroxy aromatic substitution pattern in thisExpand
Whats New in Chromatographic Enantioseparations
Progress in different areas of enantioselective chromatography and its applications in last years (2002-2003) is reviewed. Special attention is devoted to chromatographic enantioseparations ofExpand