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A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
TLDR
A cell-penetrating, protease-resistant peptide that blocks the access of JNK to many of its targets is evaluated and is found to be a promising neuroprotective agent for stroke.
Stroke incidence and prevalence in Europe: a review of available data
TLDR
Until better and more stroke studies are available, the WHO stroke estimates may provide the best data for understanding the stroke burden in countries where no stroke data currently exists.
Perfusion-CT Assessment of Infarct Core and Penumbra: Receiver Operating Characteristic Curve Analysis in 130 Patients Suspected of Acute Hemispheric Stroke
TLDR
In a large series of 130 patients, the optimal approach to define the infarct and the penumbra is a combined approach using 2 PCT parameters: relative MTT and absolute CBV, with dedicated thresholds.
The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke.
TLDR
It is believed that the Lausanne Stroke Registry is the first registry with complete computed tomography and Doppler ultrasonography data on all patients, which allows correlation between clinical findings, presumed etiology, and stroke location.
Spinal cord ischemia: clinical and imaging patterns, pathogenesis, and outcomes in 27 patients.
TLDR
The outcomes were favorable, with only 13 patients showing significant gait impairment on leaving the hospital, and the clinical data suggesting root involvement at the level of the spinal cord lesion and pointing to mechanical injury of a radicular artery.
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase
TLDR
Intravenous desmoteplase administered 3 to 9 hours after acute ischemic stroke in patients selected with perfusion/diffusion mismatch is associated with a higher rate of reperfusion and better clinical outcome compared with placebo.
Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients
TLDR
It is concluded that perfusion CT allows the accurate prediction of the final infarct size and the evaluation of clinical prognosis for acute stroke patients at the time of emergency evaluation and may also provide information about the extent of the penumbra.
Fatigue after Stroke: A Major but Neglected Issue
TLDR
The concept of ‘primary’ poststroke fatigue is emphasized, which may develop in the absence of depression or a significant cognitive sequela, and which may be linked to attentional deficits resulting from specific damage to the reticular formation and related structures involved in the subcortical attentional network.
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