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Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase*
Clones encoding a new human P2Y receptor, provisionally called P2Y11, have been isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base pair open reading frame isExpand
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Identification of a Novel Human ADP Receptor Coupled to Gi *
We have cloned and expressed a novel human G-protein-coupled receptor closely related to the human P2Y12 receptor. It corresponds to the orphan receptor called GPR86. GPR86 proved to be a Gi-coupledExpand
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Pharmacological characterization of the human P2Y11 receptor
The human P2Y11 receptor is coupled to both the phosphoinositide and the cyclic AMP pathways. A pharmacological characterization of the recombinant human P2Y11 receptor has been conducted followingExpand
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Cloning, functional expression and tissue distribution of the human P2Y6 receptor.
In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led usExpand
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Cloning and Functional Expression of a Human Uridine Nucleotide Receptor (*)
In order to isolate new subtypes of P2 purinoceptors, sets of degenerate oligonucleotide primers were synthesized on the basis of the best conserved segments in the published sequences of the chickExpand
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Pharmacological characterization of the human P2Y4 receptor.
The P2Y4 receptor is a new member of the P2Y family which functionally behaves as a pyrimidinergic receptor. The pharmacological properties of the human P2Y4 receptor have been characterizedExpand
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Plasma homocysteine concentration in a Belgian school-age population.
BACKGROUND Total plasma homocysteine (tHcy) is an independent risk factor for cardiovascular disease in adults. Data for children and adolescents are lacking. OBJECTIVE The aim of this study was toExpand
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The P2Y11 Receptor Mediates the ATP-Induced Maturation of Human Monocyte-Derived Dendritic Cells1
Recently, it has been shown that ATP and TNF-α synergize in the activation and maturation of human dendritic cells (DC); the effect of ATP was reproduced by hydrolysis-resistant derivatives of ATPExpand
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Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors.
Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two families:Expand
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Overview of the P2 receptors.
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition,Expand
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